This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Protein timeless homolog.
Negatively regulates CLOCK.
Human | |
---|---|
Gene Name: | TIMELESS |
Uniprot: | Q9UNS1 |
Entrez: | 8914 |
Belongs to: |
---|
timeless family |
FLJ12640; hTIMTIMELESS1; TIM1protein timeless homolog; timeless (Drosophila) homolog; timeless homolog (Drosophila); TIMFLJ20714
Mass (kDA):
138.658 kDA
Human | |
---|---|
Location: | 12q13.3 |
Sequence: | 12; NC_000012.12 (56416363..56449426, complement) |
Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney, placenta, pancreas, spleen, thymus and testis. Highest levels of expression in placenta, pancreas, thymus and testis.
Nucleus. Chromosome. In response to double-strand breaks (DSBs), accumulates at DNA damage sites via its interaction with PARP1.
PMID: 9891984 by Koike N., et al. Identification of the mammalian homologues of the Drosophila timeless gene, Timeless1.
PMID: 9856465 by Sangoram A.M., et al. Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-ARTNL/BMAL1-induced transcription.