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- Table of Contents
Protein timeless homolog Antibodies
AND TIMELESS ELISA kits, Protein timeless homolog Proteins
Many biological assays use antibodies to detect Protein timeless homolog, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein timeless homolog in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein timeless homolog antibodies...
Designing an IHC experiment for Protein timeless homolog? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TIMELESS IHC GuideTIMELESS Infographic by Boster Bio
All TIMELESS Products
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TIMELESS Overview
Facts about Protein timeless homolog.
Protein timeless homolog (TIMELESS)
Plays an essential part in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability during normal DNA replication and in the regulation of the circadian clock. Involved in the conclusion of period length and at the DNA damage-dependent phase advancing of the circadian clock.
Negatively regulates CLOCK.
Gene Information
| Human | |
|---|---|
| Gene Name: | TIMELESS |
| Uniprot: | Q9UNS1 |
| Entrez: | 8914 |
Family
| Belongs to: |
|---|
| timeless family |
Alternative Names
FLJ12640; hTIMTIMELESS1; TIM1protein timeless homolog; timeless (Drosophila) homolog; timeless homolog (Drosophila); TIMFLJ20714
Molecular Weight
Mass (kDA):
138.658 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.3 |
| Sequence: | 12; NC_000012.12 (56416363..56449426, complement) |
Tissue Specificity
Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney, placenta, pancreas, spleen, thymus and testis. Highest levels of expression in placenta, pancreas, thymus and testis.
Subcellular Localizations
Nucleus. Chromosome. In response to double-strand breaks (DSBs), accumulates at DNA damage sites via its interaction with PARP1.
Diseases
- Nervousness
- Neoplasms
- Sleep Disorders
- Disease Of Adrenal Medulla
- Bipolar Disorder
- Malignant Neoplasms
- Depressive Disorder
- Mental Disorders
- Mood Disorders
- Genotoxic Stress
- Schizophrenia
- Malaria
- Stress, Psychological
Interacting Proteins
- CHEK1
Pathways
- Circadian Rhythm
- Localization
- Dna Replication
- Eclosion
- Translation
- Transport
- Cell Cycle
- Locomotor Rhythm
- Circadian Behavior
- Rna Interference
- S Phase
- Rhythmic Behavior
- Mating
PTMs
- Phosphorylation
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TIMELESS
bosterbio.com/bosterbio-gene-info-cards/TIMELESS
References
PMID: 9891984 by Koike N., et al. Identification of the mammalian homologues of the Drosophila timeless gene, Timeless1.
PMID: 9856465 by Sangoram A.M., et al. Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-ARTNL/BMAL1-induced transcription.