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- Table of Contents
TLE1 Antibodies
AND TLE1 ELISA kits, TLE1 Proteins
Many biological assays use antibodies to detect TLE1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TLE1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TLE1 antibodies...
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TLE1 Infographic by Boster Bio
All TLE1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M02460
100 μl
Cat # M02460
100 μl
Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M02460-1
100 µl
Cat # M02460-1
100 µl
TLE1 Overview
Facts about Transducin-like enhancer protein 1.
Transducin-like enhancer protein 1 (TLE1)
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression.
Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The impacts of full-length TLE family members may be modulated by association with dominant-negative AES.
Gene Information
| Human | |
|---|---|
| Gene Name: | TLE1 |
| Uniprot: | Q04724 |
| Entrez: | 7088 |
Family
| Belongs to: |
|---|
| WD repeat Groucho/TLE family |
Alternative Names
E(Sp1) homolog; enhancer of split groucho 1; ESG; ESG1Enhancer of split groucho-like protein 1; GRG1; TLE1; transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 1, homolog of Drosophila E(sp1); transducin-like enhancer protein 1
Molecular Weight
Mass (kDA):
83.201 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q21.32 |
| Sequence: | 9; NC_000009.12 (81583683..81689547, complement) |
Tissue Specificity
In all tissues examined, mostly in brain, liver and muscle.
Subcellular Localizations
Nucleus. Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
Diseases
- Neoplasms
- Sarcoma
- Malignant Neoplasms
- Synovial Sarcoma
- Leukemia
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Leukemia, Myelocytic, Acute
- Soft Tissue Neoplasms
- Multiple Acyl Coenzyme A Dehydrogenase Deficiency
- Malignant Peripheral Nerve Sheath Tumor
- Leukemogenesis
- Nerve Sheath Tumors
Interacting Proteins
- HIST1H4A
- NOD2
- RUNX3
- SIRT1
Pathways
- Segmentation
- Neurogenesis
- Cell Proliferation
- Pathogenesis
- Cell Death
- Osteoblast Differentiation
- Cell Division
- Cell Differentiation
- Localization
- Neuron Differentiation
- Angiogenesis
- Hyperphosphorylation
- Cell Fate Determination
PTMs
- Phosphorylation
- Methylation
- Demethylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TLE1
bosterbio.com/bosterbio-gene-info-cards/TLE1
References
PMID: 1303260 by Stifani S., et al. Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins.
PMID: 10748198 by Wang J.-C., et al. Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.