TLE1 Antibodies

AND TLE1 ELISA kits, TLE1 Proteins

Many biological assays use antibodies to detect TLE1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TLE1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TLE1 antibodies...

We validate the specificity of these antibodies to TLE1 by testing them on tissues known to express TLE1 positively and negatively. Browse below to find the TLE1 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TLE1 Infographic by Boster Bio

All TLE1 Products

Product

Figures

Specificity

Applications

Price

Anti-TLE1/2/3/4 Antibody

Human, Mouse, Rat

IHC, WB

$399
Cat # A02460
100μl

Anti-TLE1 Rabbit Monoclonal Antibody

7 Q&As

Human, Mouse, Rat

IF, IHC, ICC, WB

$370
Cat # M02460
100 μl

Anti-TLE1 Antibody (N-term)

Human

IF, WB

$298
Cat # A02460-1
80 µl

Anti-TLE 1 (TLE1) Mouse Monoclonal Antibody [Clone ID: OTI1H2]

+19

Human, Mouse, Rat

Flow Cytometry, IF, IHC, WB

$523
Cat # M02460-1
100 µl

TLE 1 (TLE1) (NM_005077) Human Over-expression Lysate

Human

$628
Cat # LS007088
100 µg

TLE1 Overview

Facts about Transducin-like enhancer protein 1.

TLE1 3D structure. Source: alphafold

Transducin-like enhancer protein 1 (TLE1)

Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression.

Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The impacts of full-length TLE family members may be modulated by association with dominant-negative AES.

Gene Information

Human
Gene Name:	TLE1
Uniprot:	Q04724
Entrez:	7088

Family

Belongs to:

WD repeat Groucho/TLE family

Alternative Names

E(Sp1) homolog; enhancer of split groucho 1; ESG; ESG1Enhancer of split groucho-like protein 1; GRG1; TLE1; transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 1, homolog of Drosophila E(sp1); transducin-like enhancer protein 1

Molecular Weight

Mass (kDA):
83.201 kDA

Genomic Context


Human

Location:	9q21.32
Sequence:	9; NC_000009.12 (81583683..81689547, complement)

Tissue Specificity

In all tissues examined, mostly in brain, liver and muscle.

Subcellular Localizations

Nucleus. Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.

Diseases

Neoplasms
Sarcoma
Malignant Neoplasms
Synovial Sarcoma
Leukemia
Carcinoma
Malignant Paraganglionic Neoplasm
Leukemia, Myelocytic, Acute
Soft Tissue Neoplasms
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
Malignant Peripheral Nerve Sheath Tumor
Leukemogenesis
Nerve Sheath Tumors

Myeloid Leukemia
Cell Transformation, Neoplastic
Peripheral Nerve Sheath Neoplasm
Adenocarcinoma
Chromosomal Translocation
Neoplasm Metastasis
Idiopathic Hypereosinophilic Syndrome

Interacting Proteins

HIST1H4A
NOD2
RUNX3
SIRT1

Pathways

Segmentation
Neurogenesis
Cell Proliferation
Pathogenesis
Cell Death
Osteoblast Differentiation
Cell Division
Cell Differentiation
Localization
Neuron Differentiation
Angiogenesis
Hyperphosphorylation
Cell Fate Determination

Cell Cycle
Induction Of Apoptosis
Mitosis
Anoikis
Cell Growth
Rna Interference
Cell Adhesion

PTMs

Phosphorylation
Methylation
Demethylation

Biotinylation
Deacetylation
Acetylation

Oxidation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TLE1

References

PMID: 1303260 by Stifani S., et al. Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins.

PMID: 10748198 by Wang J.-C., et al. Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.