TMEM106B Antibodies

AND TMEM106B ELISA kits, TMEM106B Proteins

Many biological assays use antibodies to detect TMEM106B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TMEM106B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TMEM106B antibodies...

We validate the specificity of these antibodies to TMEM106B by testing them on tissues known to express TMEM106B positively and negatively. Browse below to find the TMEM106B antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for TMEM106B? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the TMEM106B IHC Guide

TMEM106B Infographic by Boster Bio

All TMEM106B Products

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Anti-Transmembrane protein 106B TMEM106B Antibody

Western blot analysis of TMEM106B in human brain tissue lysate with TMEM106B antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide

Human

ELISA, IF, IHC-P, WB

$481
Cat # A03541
0.1 mg

TMEM106B (NM_018374) Human Over-expression Lysate

TMEM106B Human Over-expression Lysates NM_001134232

Human

$628
Cat # LS054664
20 µg, 100 µg

TMEM106B Overview

Facts about Transmembrane protein 106B.

TMEM106B 3D structure. Source: alphafold

Transmembrane protein 106B (TMEM106B)

Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites.

Required for dendrite branching. .

Gene Information

Human
Gene Name:	TMEM106B
Uniprot:	Q9NUM4
Entrez:	54664

Family

Belongs to:

TMEM106 family

Alternative Names

TMEM106B; transmembrane protein 106B

Molecular Weight

Mass (kDA):
31.127 kDA

Genomic Context


Human

Location:	7p21.3
Sequence:	7; NC_000007.14 (12211294..12243367)

Tissue Specificity

Expressed in frontal cortex.

Subcellular Localizations

Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor.

Diseases

Frontotemporal Lobar Degeneration
Sclerosis
Dementia
Primary Lateral Sclerosis
Neurodegenerative Disorders
Amyotrophic Lateral Sclerosis
Alzheimer's Disease
Dysequilibrium Syndrome
Cholangiocarcinoma
Gliosis
Frontotemporal Dementia

Cognition Disorders
Neuropathology Disease
Depressive Disorder
Impaired Cognition
Presenile Dementia

Pathways

Transport
Glycosylation
Cognition
Pathogenesis
Localization
Secretion

PTMs

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TMEM106B

References

PMID: 20154673 by Van Deerlin V.M., et al. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.

PMID: 21178100 by Finch N., et al. TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers.