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Transmembrane protein 119 Antibodies
AND Tmem119 ELISA kits, Transmembrane protein 119 Proteins
Many biological assays use antibodies to detect Transmembrane protein 119, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transmembrane protein 119 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transmembrane protein 119 antibodies...
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Tmem119 Infographic by Boster Bio
All Tmem119 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M09325
100 μl/vial
Cat # M09325
100 μl/vial
Tmem119 Overview
Facts about Transmembrane protein 119.
Transmembrane protein 119 (Tmem119)
Plays an essential role in bone formation and normal bone mineralization (PubMed:26207632, PubMed:22416756, PubMed:20025746). Promotes the differentiation of myoblasts to osteoblasts (PubMed:22416756, PubMed:20025746, PubMed:22579779).
May induce the commitment and differentiation of myoblasts to osteoblasts through an enhancement of BMP2 creation and interaction with the BMP-RUNX2 pathway (PubMed:21239498, PubMed:22579779). Upregulates the expression of ATF4 which plays a central role in osteoblast differentiation (PubMed:24362451).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Tmem119 |
| Uniprot: | Q8R138 |
| Entrez: | 231633 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
OBIF; Osteoblast Induction Factor; TMEM119
Molecular Weight
Mass (kDA):
29.401 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 5|5 F |
| Sequence: | 5; |
Tissue Specificity
Expressed in spermatocytes and spermatids in the developing testis (at protein level). Expressed in the brain, heart, lung, spleen, skeletal muscle, ovary, testis and epididymis (PubMed:26207632). Predominantly expressed in osteoblasts (PubMed:20025746).
Diseases
- Hypoplasia
- Fibrodysplasia Ossificans Progressiva
- Heterotopic Ossification
Pathways
- Osteoblast Differentiation
- Regeneration
- Ossification
- Pathogenesis
- Bmp Signaling Pathway
PTMs
- Glycoprotein
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Tmem119
bosterbio.com/bosterbio-gene-info-cards/Tmem119
References
PMID: 20025746 by Kanamoto T., et al. Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation.
PMID: 21239498 by Hisa I., et al. Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway.