TMPRSS3 Antibodies

AND TMPRSS3 ELISA kits, TMPRSS3 Proteins

Many biological assays use antibodies to detect TMPRSS3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TMPRSS3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TMPRSS3 antibodies...

We validate the specificity of these antibodies to TMPRSS3 by testing them on tissues known to express TMPRSS3 positively and negatively. Browse below to find the TMPRSS3 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for TMPRSS3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the TMPRSS3 Western Blot Guide

TMPRSS3 Infographic by Boster Bio

All TMPRSS3 Products

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Figures

Specificity

Applications

Price

Anti-TMPRSS3 Antibody Picoband®

Western blot analysis of TMPRSS3 using anti-TMPRSS3 antibody (A04164-2)

IHC analysis of TMPRSS3 using anti-TMPRSS3 antibody (A04164-2)

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A04164-2
100 μg/vial

TMPRSS3 (NM_032401) Human Over-expression Lysate

TMPRSS3 Human Over-expression Lysates NM_032401

Human

$628
Cat # LS064699
20 µg, 100 µg

TMPRSS3 Colorimetric Cell-Based ELISA

Western blot analysis of extracts from HuvEc cells

Human, Mouse

ELISA

$480
Cat # EKC1757
1 kit, containing one 96-well plate and all necessary reagents

TMPRSS3 Overview

Facts about Transmembrane protease serine 3.

TMPRSS3 3D structure. Source: alphafold

Transmembrane protease serine 3 (TMPRSS3)

Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity).

Activates ENaC (in vitro). .

Gene Information

Human
Gene Name:	TMPRSS3
Uniprot:	P57727
Entrez:	64699

Family

Belongs to:

peptidase S1 family

Alternative Names

DFNB10; DFNB8; EC 3.4.21; EC 3.4.21.-; gene similar to transmembrane serine protease10ECHOS1Serine protease TADG-12; serine protease TADG12; TADG12; transmembrane protease serine 3; transmembrane protease, serine 3; Tumor-associated differentially-expressed gene 12 protein

Molecular Weight

Mass (kDA):
49.405 kDA

Genomic Context


Human

Location:	21q22.3
Sequence:	21; NC_000021.9 (42371837..42396052, complement)

Tissue Specificity

Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas.

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Diseases

Complete Hearing Loss
Malignant Neoplasms
Neoplasms
Deafness Congenital
Sensorineural Hearing Loss (disorder)
Carcinoma
Epithelial Ovarian Cancer
Ovarian Neoplasm
Prostatic Neoplasms
Malignant Neoplasm Of Ovary
Neoplasm Metastasis
Adenocarcinoma

Epilepsy
Inflammation
Pancreatic Neoplasm
Malignant Neoplasm Of Pancreas
Malignant Neoplasm Of Prostate
Hearing Loss, Bilateral
Genetic Diseases, Inborn

Pathways

Transport
Methylation
Translation
Dna Hypomethylation
Proteolysis
Interferon-gamma Production
Dna Methylation

Localization
Secretion

PTMs

Cleavage

Glycosylation

Methylation

Research Areas

Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TMPRSS3

References

PMID: 11068177 by Underwood L.J., et al. Ovarian tumor cells express a novel multi-domain cell surface serine protease.

PMID: 11137999 by Scott H.S., et al. Insertion of beta-satellite repeats identifies a transmembrane protease causing both congenital and childhood onset autosomal recessive deafness.