Tropomyosin beta chain Antibodies

AND TPM2 ELISA kits, Tropomyosin beta chain Proteins

Many biological assays use antibodies to detect Tropomyosin beta chain, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tropomyosin beta chain in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tropomyosin beta chain antibodies...

We validate the specificity of these antibodies to Tropomyosin beta chain by testing them on tissues known to express TPM2 positively and negatively. Browse below to find the TPM2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Tropomyosin beta chain? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the TPM2 IHC Guide

TPM2 Infographic by Boster Bio

All TPM2 Products

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Specificity

Applications

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Anti-Tropomyosin 2/TPM2 Antibody Picoband®

Western blot analysis of Tropomyosin 2/TPM2 using anti-Tropomyosin 2/TPM2 antibody (A03082-1)

IHC analysis of Tropomyosin 2/TPM2 using anti-Tropomyosin 2/TPM2 antibody (A03082-1)

Human, Mouse, Rat

Flow Cytometry, IF, IHC, WB

$370
Cat # A03082-1
100 μg/vial

Tropomyosin 2 (TPM2) (NM_003289) Human Over-expression Lysate

Human

$628
Cat # LS007169
20 µg, 100 µg

Tropomyosin 2 (TPM2) (NM_213674) Human Recombinant Protein

Coomassie blue staining of purified TPM2 protein

$1249
Cat # PROTP07951
20 µg

TPM2 Overview

Facts about Tropomyosin beta chain.

TPM2 3D structure. Source: alphafold

Tropomyosin beta chain (TPM2)

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction.

Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

Gene Information

Human
Gene Name:	TPM2
Uniprot:	P07951
Entrez:	7169

Family

Belongs to:

tropomyosin family

Alternative Names

distal, type 1; tropomyosin 2 (beta)

Molecular Weight

Mass (kDA):
32.851 kDA

Genomic Context


Human

Location:	9p13.3
Sequence:	9; NC_000009.12 (35681993..35690056, complement)

Tissue Specificity

Present in primary breast cancer tissue, absent from normal breast tissue.

Subcellular Localizations

Cytoplasm, cytoskeleton. Associates with F-actin stress fibers.

Diseases

Myopathy
Weakness
Arthrogryposis
Muscle Weakness
Myopathies, Nemaline
Distal Arthrogryposis Syndrome
Congenital Myopathy (disorder)
Muscle Contracture
Malignant Neoplasms
Neoplasms
Congenital Structural Myopathy
Congenital Abnormality

Neuromuscular Diseases
Arthrogryposis, Distal, Type 2b
Congenital Fiber Type Disproportion
Freeman-sheldon Syndrome
Congenital Clubfoot
Carcinoma

Pathways

Muscle Contraction
Localization
Pathogenesis
Cell Motility
Transport
Cell Migration
Regulation Of Muscle Contraction
Cell Proliferation
Methylation
Cell Adhesion
Regulation Of Cytoskeleton
Cytokinesis
Reverse Transcription

Cell Cycle
Cell Differentiation
Cell Communication
Dna Methylation
Metaphase
Endocytosis
Ovulation

PTMs

Methylation
Demethylation

Cleavage
Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TPM2

References

PMID: 3865200 by MacLeod A.R., et al. A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism.

PMID: 3368322 by Widada J.S., et al. Complete nucleotide sequence of the adult skeletal isoform of human skeletal muscle beta-tropomyosin.