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- Table of Contents
TRAF5 Antibodies
AND TRAF5 ELISA kits, TRAF5 Proteins
Many biological assays use antibodies to detect TRAF5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRAF5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRAF5 antibodies...
Designing a Western blot for TRAF5? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TRAF5 Western Blot GuideTRAF5 Infographic by Boster Bio
All TRAF5 Products
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TRAF5 Overview
Facts about TNF receptor-associated factor 5.
TNF receptor-associated factor 5 (TRAF5)
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and likely JNK.
Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
Gene Information
| Human | |
|---|---|
| Gene Name: | TRAF5 |
| Uniprot: | O00463 |
| Entrez: | 7188 |
Family
| Belongs to: |
|---|
| TNF receptor-associated factor family |
Alternative Names
MGC:39780; RNF84; RNF84RING finger protein 84; TNF receptor-associated factor 5; TRAF5; TRAF-5
Molecular Weight
Mass (kDA):
64.406 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q32.3 |
| Sequence: | 1; NC_000001.11 (211326594..211374946) |
Tissue Specificity
Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.
Subcellular Localizations
Cytoplasm. Cytoplasm, cytosol.
Diseases
- Neoplasms
- Lymphoma
- Inflammation
- Malignant Neoplasms
- Tissue Adhesions
- B-cell Lymphomas
- Leukemia
- Autoimmunity
- Hodgkin Disease
- Autoimmune Reaction
- Immunologic Deficiency Syndromes
- Lymphoma, Non-hodgkin
- Leukemogenesis
Interacting Proteins
- CCDC184
- FBXO28
- GORASP2
- HOMER1
- HSF2BP
- NMI
- RAD23A
- SDCBP
- SEC13
- SERPINB9
Pathways
- Cell Death
- Immune Response
- Cell Activation
- Cell Proliferation
- Pathogenesis
- Osteoclast Differentiation
- Localization
- Cell Growth
- Secretion
- T Cell Activation
- Cell Differentiation
- Cytokine Production
- Angiogenesis
PTMs
- Phosphorylation
- Ubiquitination
Research Areas
- Apoptosis
- Signal Transduction
- Zinc Finger
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRAF5
bosterbio.com/bosterbio-gene-info-cards/TRAF5
References
PMID: 9511754 by Mizushima S., et al. Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).
PMID: 9177772 by Nakano H., et al. Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32.