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TRAF7 Antibodies
AND TRAF7 ELISA kits, TRAF7 Proteins
Many biological assays use antibodies to detect TRAF7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRAF7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRAF7 antibodies...
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TRAF7 Infographic by Boster Bio
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TRAF7 Overview
Facts about E3 ubiquitin-protein ligase TRAF7.
E3 ubiquitin-protein ligase TRAF7 (TRAF7)
E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators.
Induces apoptosis when overexpressed. .
Gene Information
| Human | |
|---|---|
| Gene Name: | TRAF7 |
| Uniprot: | Q6Q0C0 |
| Entrez: | 84231 |
Family
| Belongs to: |
|---|
| WD repeat TRAF7 family |
Alternative Names
DKFZp586I021; E3 ubiquitin-protein ligase TRAF7; EC 6.3.2.-; MGC7807; RFWD1RING finger protein 119; RNF119RING finger and WD repeat-containing protein 1; TNF receptor-associated factor 7ring finger and WD repeat domain 1
Molecular Weight
Mass (kDA):
74.609 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p13.3 |
| Sequence: | 16; NC_000016.10 (2155778..2178129) |
Tissue Specificity
Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.
Subcellular Localizations
Cytoplasmic vesicle. Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.
Diseases
- Neoplasms
- Inflammation
- Sclerosis
- Malignant Neoplasm Of Breast
- Communicable Diseases
- Inflammatory Response
- Misalignment
- Malignant Neoplasms
- Nervousness
- Innate Immune Response
- Mammary Neoplasms
- Bacterial Infections
Interacting Proteins
- MAP3K3
- Ripk4
Pathways
- Cell Cycle
- Cell Death
- Immune Response
- Innate Immune Response
- Dna Repair
- Rna Interference
PTMs
- Ubiquitination
Research Areas
- Lipid and Metabolism
- Zinc Finger
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRAF7
bosterbio.com/bosterbio-gene-info-cards/TRAF7
References
PMID: 15001576 by Xu L.-G., et al. TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis.
PMID: 14743216 by Bouwmeester T., et al. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.