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- Table of Contents
Triadin Antibodies
AND TRDN ELISA kits, Triadin Proteins
Many biological assays use antibodies to detect Triadin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Triadin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Triadin antibodies...
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TRDN Infographic by Boster Bio
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TRDN Overview
Facts about Triadin.
Triadin (TRDN)
Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity).
Required for normal skeletal muscle strength. Plays a role in excitation- contraction coupling in the heart and in regulating the rate of heart beats.
Gene Information
| Human | |
|---|---|
| Gene Name: | TRDN |
| Uniprot: | Q13061 |
| Entrez: | 10345 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
dJ166D18.1 (triadin); TDN; triadin; TRISK
Molecular Weight
Mass (kDA):
81.595 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q22.31 |
| Sequence: | 6; NC_000006.12 (123216339..123637093, complement) |
Subcellular Localizations
Cell membrane. Sarcoplasmic reticulum membrane; Single-pass type II membrane protein.
Diseases
- Cardiac Arrhythmia
- Hypertrophy
- Tachycardia, Ventricular
- Endometriosis, Site Unspecified
- Polymorphic Ventricular Tachycardia
- Cardiac Hypertrophy
- Heart Failure
- Ventricular Tachycardia, Catecholaminergic Polymorphic, 1 (disorder)
- Sudden Cardiac Death
- Muscular Atrophy
- Cardiac Death
- Respiratory Distress Syndrome, Newborn
- Ataxia
Pathways
- Localization
- Cell Proliferation
- Glycosylation
- Transport
- Translation
- Induction Of Apoptosis
- Aging
- Muscle Contraction
- Cell Death
- Dedifferentiation
- Mesenchyme Development
PTMs
- Phosphorylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRDN
bosterbio.com/bosterbio-gene-info-cards/TRDN
References
PMID: 7588753 by Taske N.L., et al. Molecular cloning of the cDNA encoding human skeletal muscle triadin and its localisation to chromosome 6q22-6q23.
PMID: 15485681 by Houle T.D., et al. Calsequestrin mutant D307H exhibits depressed binding to its protein targets and a depressed response to calcium.