E3 ubiquitin-protein ligase TRIM22 (TRIM22)

Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could be mediated by TRIM22-dependent ubiquitination of viral proteins.

Plays a role in limiting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter.