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- Table of Contents
Facts about E3 ubiquitin-protein ligase TRIM22.
Plays a role in limiting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter.
Human | |
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Gene Name: | TRIM22 |
Uniprot: | Q8IYM9 |
Entrez: | 10346 |
Belongs to: |
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TRIM/RBCC family |
50 kDa-stimulated trans-acting factor; E3 ubiquitin-protein ligase TRIM22; EC 6.3.2; EC 6.3.2.-; GPSTAF50; RING finger protein 94; RNF94stimulated trans-acting factor (50 kDa); Staf-50; STAF50staf-50; tripartite binding motif 22; tripartite motif containing 22; tripartite motif protein TRIM22; tripartite motif-containing 22; Tripartite motif-containing protein 22
Mass (kDA):
56.947 kDA
Human | |
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Location: | 11p15.4 |
Sequence: | 11; NC_000011.10 (5689790..5710863) |
Strongly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. Expressed at basal levels in other tissues.
Cytoplasm. Nucleus. Nucleus speckle. Nucleus, Cajal body. Localizes predominantly to the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies.
PMID: 7797467 by Tissot C., et al. Molecular cloning of a new interferon-induced factor that represses human immunodeficiency virus type 1 long terminal repeat expression.
PMID: 11331580 by Reymond A., et al. The tripartite motif family identifies cell compartments.