- Table of Content
May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation.
|ABC transporter superfamily|
|Sequence:||19; NC_000019.10 (1040107..1065572)|
Expressed in leukocytes (at protein level). Widely expressed. Highly expressed in myelo-lymphatic tissues including peripheral leukocytes, thymus, spleen and bone marrow. Isoform 2 is more abundant in lymph node, spleen, thymus and trachea than isoform 1 which is more strongly expressed in brain and bone marrow.
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cytoplasm. Cell projection, ruffle membrane. Cell projection, phagocytic cup. Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney (By similarity).; [Isoform 2]: Cytoplasm. Endoplasmic reticulum. May localize to the endoplasmi