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- Table of Contents
TRIM28 Antibodies
AND TRIM28 ELISA kits, TRIM28 Proteins
Many biological assays use antibodies to detect TRIM28, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRIM28 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRIM28 antibodies...
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TRIM28 Infographic by Boster Bio
All TRIM28 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9835
100 μg/vial
Cat # PB9835
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00409
100 μl
Cat # M00409
100 μl
Human, Mouse, Rat
Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # M00409-1
100 μg/vial
Cat # M00409-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # M00409-2
100 μg/vial
Cat # M00409-2
100 μg/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00409-4
20μL, 40μL, 100μL, 200μL
Cat # M00409-4
20μL, 40μL, 100μL, 200μL
TRIM28 Overview
Facts about Transcription intermediary factor 1-beta.
Transcription intermediary factor 1-beta (TRIM28)
Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the rise in H3K9me, the reduction in histone H3'Lys-9 and'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression.
Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation.
Gene Information
| Human | |
|---|---|
| Gene Name: | TRIM28 |
| Uniprot: | Q13263 |
| Entrez: | 10155 |
Family
| Belongs to: |
|---|
| TRIM/RBCC family |
Alternative Names
E3 SUMO-protein ligase TRIM28; EC 6.3.2.-; FLJ29029; KAP1; KAP-1; KAP1KRAB-associated protein 1; KRIP-1; Nuclear corepressor KAP-1; RNF96; RNF96KRAB-interacting protein 1; TF1B; TIF1B; TIF1-beta; TIF1BRING finger protein 96; transcription intermediary factor 1-beta; transcriptional intermediary factor 1-beta; TRIM28; tripartite motif containing 28; tripartite motif-containing 28; Tripartite motif-containing protein 28
Molecular Weight
Mass (kDA):
88.55 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.43 |
| Sequence: | 19; NC_000019.10 (58544064..58550722) |
Tissue Specificity
Expressed in all tissues tested including spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.
Subcellular Localizations
Nucleus. Associated with centromeric heterochromatin during cell differentiation through CBX1.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Ataxia
- Ataxia Telangiectasia
- Leukemia
- Telangiectasis
- Immunologic Deficiency Syndromes
- Malignant Neoplasm Of Breast
- Embryonal Carcinoma
- Leukoencephalopathy, Progressive Multifocal
- Mammary Neoplasms
Interacting Proteins
- Cbx1
- CBX3
- Cbx3
- CBX5
- CHD3
- MAGEA2
- MAGEA3
- MAGEA6
- MAGEC2
- MAGEE1
Pathways
- Gene Silencing
- Methylation
- Cell Cycle
- Chromatin Remodeling
- Dna Repair
- Dna Methylation
- Cell Differentiation
- Cell Proliferation
- Cell Growth
- Interphase
- Histone Deacetylation
- Dna Replication
- Cell Cycle Checkpoint
PTMs
- Phosphorylation
- Methylation
- Acetylation
- Sumoylation
Research Areas
- Phospho-Specific
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRIM28
bosterbio.com/bosterbio-gene-info-cards/TRIM28
References
PMID: 8769649 by Friedman J.R., et al. KAP-1, a novel corepressor for the highly conserved KRAB repression domain.
PMID: 9016654 by Moosmann P.R., et al. Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1.
1 Publications of Boster TRIM28 Antibodies & ELISA Kits
- PubMed ID: 33385414, Hao Y,Bai S,Peng J,Hong R,Ding J,Li Z,Guan Y.TRIM27-mediated ubiquitination of P...
*More publications can be found for each product on its corresponding product page