This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about E3 ubiquitin-protein ligase TTC3.
Catalyzes the formation of 'Lys-48'- polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.
Human | |
---|---|
Gene Name: | TTC3 |
Uniprot: | P53804 |
Entrez: | 7267 |
Belongs to: |
---|
No superfamily |
DCRR1tetratricopeptide repeat protein 3 (TPR repeat protein D)10RNF105DKFZp686M0150; E3 ubiquitin-protein ligase TTC3; EC 6.3.2.-; Protein DCRR1; RING finger protein 105; tetratricopeptide repeat domain 3; Tetratricopeptide repeat protein 3; TPR repeat protein 3; TPR repeat protein D; TPRDI; TPRDII; TPRDTPRDIII
Mass (kDA):
229.869 kDA
Human | |
---|---|
Location: | 21q22.13 |
Sequence: | 21; NC_000021.9 (37073184..37203118) |
Found in all tissues examined.
Nucleus. Cytoplasm. Golgi apparatus. Nuclear localization may be dependent on the proteolytic cleavage of full length protein in the cytoplasm (PubMed:30203323). This cleavage may reveal an N-terminal nuclear localization signal, allowing N-terminal fragments to enter the nucleus (PubMed:30203323).
PMID: 8724848 by Ohira M., et al. Identification of a novel human gene containing the tetratricopeptide repeat domain from the Down syndrome region of chromosome 21.
PMID: 8947847 by Tsukahara F., et al. Identification and cloning of a novel cDNA belonging to tetratricopeptide repeat gene family from Down syndrome-critical region 21q22.2.