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- Table of Contents
TTC5 Antibodies
AND TTC5 ELISA kits, TTC5 Proteins
Many biological assays use antibodies to detect TTC5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TTC5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TTC5 antibodies...
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TTC5 Overview
Facts about Tetratricopeptide repeat protein 5.
Tetratricopeptide repeat protein 5 (TTC5)
Adapter protein involved in p53/TP53 reaction that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis.
Prevents p53/TP53 degradation by MDM2 (By similarity). .
Gene Information
| Human | |
|---|---|
| Gene Name: | TTC5 |
| Uniprot: | Q8N0Z6 |
| Entrez: | 91875 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Strap; tetratricopeptide repeat domain 5; tetratricopeptide repeat protein 5; TPR repeat protein 5
Molecular Weight
Mass (kDA):
48.928 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q11.2 |
| Sequence: | 14; NC_000014.9 (20286227..20305951, complement) |
Subcellular Localizations
Nucleus. Cytoplasm. Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm.
Diseases
- Physiological Stress
Interacting Proteins
- CAMK2B
- CAMK2D
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TTC5
bosterbio.com/bosterbio-gene-info-cards/TTC5
References
PMID: 22362889 by Adams C.J., et al. The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.