TTK Antibodies

AND TTK ELISA kits, TTK Proteins

Many biological assays use antibodies to detect TTK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TTK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TTK antibodies...

We validate the specificity of these antibodies to TTK by testing them on tissues known to express TTK positively and negatively. Browse below to find the TTK antibody that suites your experiment. We have 7 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TTK Infographic by Boster Bio

All TTK Products

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Anti-TTK/Mps1/TTK Antibody Picoband®

1 Citations

Western blot analysis of TTK using anti-TTK antibody (A01132-1)

IHC analysis of TTK using anti-TTK antibody (A01132-1)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A01132-1
100 μg/vial

Anti-Phospho-TTK (T676) Antibody

Immunohistochemical analysis of paraffin-embedded Human brain

Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using TTK (Phospho-Thr676) Antibody

Human, Mouse

ELISA, IF, IHC

$380
Cat # A01132T676
100ul

Anti-TTK Antibody

Human, Mouse

ELISA, IF, IHC, WB

$380
Cat # A01132-2
100ul

Mps1 (TTK) (NM_003318) Human Recombinant Protein

Coomassie blue staining of purified TTK protein

$1249
Cat # PROTP33981
20 µg

Anti-Mps1 (TTK) Mouse Monoclonal Antibody [Clone ID: OTI1D4]

Western blot analysis of extracts (35ug) from 3 different cell lines by using anti-TTK monoclonal antibody (1:500)

Human

$523
Cat # M01132
100 µl

Mps1 (TTK) (NM_003318) Human Over-expression Lysate

Human

$628
Cat # LS007272
20 µg, 100 µg

Anti-Phospho-TTK (T676) Antibody

Human, Mouse, Rat

IHC, WB

$370
Cat # P01132
100 μl/vial

TTK Overview

Facts about Dual specificity protein kinase TTK.

TTK 3D structure. Source: alphafold

Dual specificity protein kinase TTK (TTK)

Phosphorylates proteins on serine, threonine, and tyrosine. Probably related to cell proliferation.

Essential for chromosome alignment by enhancing AURKB action (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint. .

Gene Information

Human
Gene Name:	TTK
Uniprot:	P33981
Entrez:	7272

Family

Belongs to:

protein kinase superfamily

Alternative Names

CT96; dual specificity protein kinase TTK; EC 2.7.12.1; ESK; FLJ38280; monopolar spindle 1-like 1; Mps1; MPS1L1; MPS1L1PYTcancer/testis antigen 96; phosphotyrosine picked threonine kinase; Phosphotyrosine picked threonine-protein kinase; PYT; TTK protein kinase; TTK

Molecular Weight

Mass (kDA):
97.072 kDA

Genomic Context


Human

Location:	6q14.1
Sequence:	6; NC_000006.12 (80004147..80042651)

Tissue Specificity

Present in rapidly proliferating cell lines.

Diseases

Malignant Neoplasms
Neoplasms
Aneuploidy
Carcinoma
Cell Transformation, Neoplastic
Nervousness
Esophageal Neoplasms
Malignant Paraganglionic Neoplasm
Malignant Neoplasm Of Breast
Mammary Neoplasms
Carcinogenesis
Squamous Cell Carcinoma Of Esophagus

Malignant Squamous Cell Neoplasm
Colorectal Cancer
Neoplasm Metastasis
Instabilities, Chromosomal
Adenocarcinoma
Cytogenetic Abnormality
Tissue Adhesions

Interacting Proteins

NDC80
NUF2

Pathways

Mitosis
Cell Cycle
Spindle Assembly
Spindle Assembly Checkpoint
Spindle Checkpoint
Chromosome Segregation
Localization
Cell Proliferation
Anaphase
Centrosome Duplication
Cell Division
Cell Death
Interphase

S Phase
Kinetochore Localization
Cell Differentiation
Segmentation
Eye Development
Cell Fate Specification
Oogenesis

PTMs

Phosphorylation
Methylation
Ubiquitination

Cleavage
Deacetylation
Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TTK

References

PMID: 1639825 by Mills G.B., et al. Expression of TTK, a novel human protein kinase, is associated with cell proliferation.

PMID: 7678926 by Lindberg R.A., et al. Characterization of a human protein threonine kinase isolated by screening an expression library with antibodies to phosphotyrosine.