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- Table of Contents
TTK Antibodies
AND TTK ELISA kits, TTK Proteins
Many biological assays use antibodies to detect TTK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TTK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TTK antibodies...
Designing a Western blot for TTK? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TTK Western Blot GuideDesigning an IHC experiment for TTK? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TTK IHC GuideTTK Infographic by Boster Bio
All TTK Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01132-1
100 μg/vial
Cat # A01132-1
100 μg/vial
TTK Overview
Facts about Dual specificity protein kinase TTK.
Dual specificity protein kinase TTK (TTK)
Phosphorylates proteins on serine, threonine, and tyrosine. Probably related to cell proliferation.
Essential for chromosome alignment by enhancing AURKB action (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint. .
Gene Information
| Human | |
|---|---|
| Gene Name: | TTK |
| Uniprot: | P33981 |
| Entrez: | 7272 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
CT96; dual specificity protein kinase TTK; EC 2.7.12.1; ESK; FLJ38280; monopolar spindle 1-like 1; Mps1; MPS1L1; MPS1L1PYTcancer/testis antigen 96; phosphotyrosine picked threonine kinase; Phosphotyrosine picked threonine-protein kinase; PYT; TTK protein kinase; TTK
Molecular Weight
Mass (kDA):
97.072 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q14.1 |
| Sequence: | 6; NC_000006.12 (80004147..80042651) |
Tissue Specificity
Present in rapidly proliferating cell lines.
Diseases
- Malignant Neoplasms
- Neoplasms
- Aneuploidy
- Carcinoma
- Cell Transformation, Neoplastic
- Nervousness
- Esophageal Neoplasms
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Carcinogenesis
- Squamous Cell Carcinoma Of Esophagus
Interacting Proteins
- NDC80
- NUF2
Pathways
- Mitosis
- Cell Cycle
- Spindle Assembly
- Spindle Assembly Checkpoint
- Spindle Checkpoint
- Chromosome Segregation
- Localization
- Cell Proliferation
- Anaphase
- Centrosome Duplication
- Cell Division
- Cell Death
- Interphase
PTMs
- Phosphorylation
- Methylation
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TTK
bosterbio.com/bosterbio-gene-info-cards/TTK
References
PMID: 1639825 by Mills G.B., et al. Expression of TTK, a novel human protein kinase, is associated with cell proliferation.
PMID: 7678926 by Lindberg R.A., et al. Characterization of a human protein threonine kinase isolated by screening an expression library with antibodies to phosphotyrosine.