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- Table of Contents

Facts about Tyrosinase.
In addition to hydroxylating tyrosine to DOPA (3,4- dihydroxyphenylalanine), also catalyzes the oxidation of DOPA into DOPA-quinone, and possibly the oxidation of DHI (5,6- dihydroxyindole) into indole-5,6 quinone. .
| Human | |
|---|---|
| Gene Name: | TYR |
| Uniprot: | P14679 |
| Entrez: | 7299 |

| Belongs to: |
|---|
| tyrosinase family |

CMM8; EC 1.14.18.1; LB24-AB; Monophenol monooxygenase; OCA1A; OCAIA; SHEP3; SK29-AB; Tumor rejection antigen AB; tyrosinase (oculocutaneous albinism IA); tyrosinase
Mass (kDA):
60.393 kDA

| Human | |
|---|---|
| Location: | 11q14.3 |
| Sequence: | 11; NC_000011.10 (89177565..89295759) |
Melanosome membrane; Single-pass type I membrane protein. Melanosome. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.





PMID: 1903356 by Giebel L.B., et al. Organization and nucleotide sequences of the human tyrosinase gene and a truncated tyrosinase-related segment.
PMID: 2823263 by Kwon B.S., et al. Isolation and sequence of a cDNA clone for human tyrosinase that maps at the mouse c-albino locus.