Many biological assays use antibodies to detect Tyrosinase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tyrosinase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tyrosinase antibodies...
We validate the specificity of these antibodies to Tyrosinase by testing them on tissues known to express TYR positively and negatively. Browse below to find the TYR antibody that suites your experiment. We have 41 of these antibodies and many publications and validation images.
If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.
Designing a Western blot for Tyrosinase?
The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
$540 Cat # EKC2392 1 kit, containing two 96-well plates and all necessary reagents
TYR Overview
Facts about Tyrosinase.
Tyrosinase (TYR)
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions resulting in melanin production from tyrosine.
In addition to hydroxylating tyrosine to DOPA (3,4- dihydroxyphenylalanine), also catalyzes the oxidation of DOPA into DOPA-quinone, and possibly the oxidation of DHI (5,6- dihydroxyindole) into indole-5,6 quinone. .
Melanosome membrane; Single-pass type I membrane protein. Melanosome. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.
Diseases
Neoplasms
Malignant Neoplasms
Tissue Adhesions
Carcinoma
Melanoma
Albinism
Pituitary Diseases
Neoplasm Metastasis
Diabetes Mellitus
Albinism, Oculocutaneous
Inflammation
Nervousness
Malignant Paraganglionic Neoplasm
Immunologic Deficiency Syndromes
Mammary Neoplasms
Malignant Neoplasm Of Breast
Cell Transformation, Neoplastic
Hiv Infections
Leukemia
Insulin Resistance
Pathways
Transport
Localization
Secretion
Proteolysis
Cell Proliferation
Translation
Pigmentation
Cell Cycle
Pathogenesis
Cell Growth
Cell Adhesion
Immune Response
Cell Death
Glycosylation
Cell Migration
Endocytosis
Protein Phosphorylation
Excretion
Protein Folding
Methylation
PTMs
Phosphorylation
Cleavage
Oxidation
Dephosphorylation
Nitration
Reduction
Iodination
Glycosylation
Methylation
Carboxylation
Acetylation
Hydroxylation
Amidation
Acylation
Decarboxylation
Amination
Deamination
Ubiquitination
Biotinylation
Ribosylation
Research Areas
Lipid and Metabolism
For details, visit: bosterbio.com/bosterbio-gene-info-cards/TYR
References
PMID: 1903356 by Giebel L.B., et al. Organization and nucleotide sequences of the human tyrosinase gene and a truncated tyrosinase-related segment.
PMID: 2823263 by Kwon B.S., et al. Isolation and sequence of a cDNA clone for human tyrosinase that maps at the mouse c-albino locus.