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- Table of Contents
TREM2 Antibodies
AND TREM2 ELISA kits, TREM2 Proteins
Many biological assays use antibodies to detect TREM2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TREM2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TREM2 antibodies...
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TREM2 Infographic by Boster Bio
All TREM2 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK1678
96 wells/kit, with removable strips.
Cat # EK1678
96 wells/kit, with removable strips.
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M02150
100 μg
Cat # M02150
100 μg
TREM2 Overview
Facts about Triggering receptor expressed on myeloid cells 2.
Triggering receptor expressed on myeloid cells 2 (TREM2)
Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | TREM2 |
| Uniprot: | Q9NZC2 |
| Entrez: | 54209 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
PLOSL2; TREM2; TREM-2; Trem2a; Trem2b; Trem2c; TREM-2triggering receptor expressed on myeloid cells 2a; Triggering receptor expressed on monocytes 2; triggering receptor expressed on myeloid cells 2
Molecular Weight
Mass (kDA):
25.447 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.1 |
| Sequence: | 6; NC_000006.12 (41158508..41163116, complement) |
Tissue Specificity
Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord.
Subcellular Localizations
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.
Diseases
- Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy
- Dementia
- Bone Cysts
- Inflammation
- Presenile Dementia
- Leukoencephalopathies
- Nerve Degeneration
- Alzheimer's Disease
- Nervousness
- Inflammatory Response
- Hereditary Diseases
- Autoimmune Reaction
Interacting Proteins
- APOE
- APP
- PSEN1
- TYROBP
Pathways
- Phagocytosis
- Immune Response
- Inflammatory Response
- Pathogenesis
- Osteoclast Differentiation
- Bone Resorption
- Cell Activation
- Secretion
- Osteoclast Development
- Innate Immune Response
- Cytokine Production
- Chemotaxis
- Macrophage Activation
PTMs
- Phosphorylation
- Biotinylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TREM2
bosterbio.com/bosterbio-gene-info-cards/TREM2
References
PMID: 10799849 by Bouchon A., et al. Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes.
PMID: 11602640 by Bouchon A., et al. A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells.