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- Table of Contents
Tribbles homolog 1 Antibodies
AND TRIB1 ELISA kits, Tribbles homolog 1 Proteins
Many biological assays use antibodies to detect Tribbles homolog 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tribbles homolog 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tribbles homolog 1 antibodies...
Designing a Western blot for Tribbles homolog 1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TRIB1 Western Blot GuideTRIB1 Infographic by Boster Bio
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TRIB1 Overview
Facts about Tribbles homolog 1.
Tribbles homolog 1 (TRIB1)
Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797).
Serves to change COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797).
Gene Information
| Human | |
|---|---|
| Gene Name: | TRIB1 |
| Uniprot: | Q96RU8 |
| Entrez: | 10221 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
C8FWG-protein-coupled receptor induced protein; GIG-2; GIG2G-protein-coupled receptor-induced protein 2; G-protein-coupled receptor-induced gene 2 protein; SKIP1; TRB-1; TRB1phosphoprotein regulated by mitogenic pathways; tribbles homolog 1 (Drosophila); tribbles homolog 1; tribbles-like protein 1
Molecular Weight
Mass (kDA):
41.009 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q24.13 |
| Sequence: | 8; NC_000008.11 (125430290..125438405) |
Tissue Specificity
Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow.
Diseases
- Leukemia
- Leukemia, Myelocytic, Acute
- Myeloid Leukemia
- Neoplasms
- Malignant Neoplasms
- Diabetes Mellitus
- Cardiovascular Diseases
- Diabetes Mellitus, Non-insulin-dependent
- Heart Diseases
- Leukemogenesis
- Coronary Artery Disease
- Cytogenetic Abnormality
- Coronary Heart Disease
Interacting Proteins
- STK40
Pathways
- Cell Proliferation
- Pathogenesis
- Mitosis
- Transport
- Smooth Muscle Cell Proliferation
- Muscle Cell Proliferation
- Dna Methylation
- Intracellular Signal Transduction
- Neutrophil Activation
- Methylation
- Dna Replication
- Chemotaxis
- Cell Death
PTMs
- Phosphorylation
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRIB1
bosterbio.com/bosterbio-gene-info-cards/TRIB1
References
PMID: 15299019 by Kiss-Toth E., et al. Human tribbles, a protein family controlling mitogen-activated protein kinase cascades.
PMID: 9342215 by Wilkin F., et al. Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells.