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- Table of Contents
TUSC3 Antibodies
AND TUSC3 ELISA kits, TUSC3 Proteins
Many biological assays use antibodies to detect TUSC3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TUSC3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TUSC3 antibodies...
Designing an IHC experiment for TUSC3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TUSC3 IHC GuideTUSC3 Infographic by Boster Bio
All TUSC3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1797
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1797
1 kit, containing one 96-well plate and all necessary reagents
TUSC3 Overview
Facts about Tumor suppressor candidate 3.
Tumor suppressor candidate 3 (TUSC3)
Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates.
Specifically necessary for the glycosylation of a subset of acceptor sites that are close cysteine residues; in this event appears to act redundantly with MAGT1. In its oxidized form suggested to form transient mixed disulfides with a glycoprotein substrate to ease access to STT3B to the unmodified acceptor site.
Gene Information
| Human | |
|---|---|
| Gene Name: | TUSC3 |
| Uniprot: | Q13454 |
| Entrez: | 7991 |
Family
| Belongs to: |
|---|
| OST3/OST6 family |
Alternative Names
D8S1992; M33; N33MRT7MGC13453; oligosaccharyltransferase 3 homolog A; OST3A; Protein N33; Putative prostate cancer tumor suppressor; tumor suppressor candidate 3
Molecular Weight
Mass (kDA):
39.676 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p22 |
| Sequence: | 8; NC_000008.11 (15540087..15766649) |
Tissue Specificity
Expressed in most non-lymphoid cells and tissues examined, including prostate, lung, liver, colon, heart, kidney and pancreas.
Subcellular Localizations
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Pancreatic Neoplasm
- Malignant Neoplasm Of Pancreas
- Adenocarcinoma
- Malignant Bone Neoplasm
- Pregnancy Complications
- Malignant Neoplasm Of Breast
- Bone Neoplasms
- Lung Diseases
- Pre-eclampsia
- Unbalanced Translocation
Pathways
- Glycosylation
- Methylation
- Transport
- Protein Glycosylation
- Reverse Transcription
- Brain Development
- Aging
- Dna Methylation
PTMs
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TUSC3
bosterbio.com/bosterbio-gene-info-cards/TUSC3
References
PMID: 8661104 by Macgrogan D., et al. Structure and methylation-associated silencing of a gene within a homozygously deleted region of human chromosome band 8p22.
PMID: 12887896 by Kelleher D.J., et al. Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties.