NEDD8-conjugating enzyme Ubc12 (UBE2M)

Accepts the ubiquitin-like protein NEDD8 in the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4.

Involved in cell proliferation. .