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- Table of Contents
UBE3A Antibodies
AND UBE3A ELISA kits, UBE3A Proteins
Many biological assays use antibodies to detect UBE3A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UBE3A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UBE3A antibodies...
Designing a Western blot for UBE3A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the UBE3A Western Blot GuideDesigning an IHC experiment for UBE3A? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the UBE3A IHC GuideUBE3A Infographic by Boster Bio
All UBE3A Products
Product
Figures
Specificity
Applications
Price
Anti-UBE3A Picoband® Antibody
1 Citations
Human
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00582
100 μg/vial
Cat # A00582
100 μg/vial
Human, Monkey
Flow Cytometry, WB
$370
Cat # M00582-2
100 μg/vial
Cat # M00582-2
100 μg/vial
Human, Monkey
Flow Cytometry, WB
$370
Cat # M00582-1
100 μg/vial
Cat # M00582-1
100 μg/vial
UBE3A Overview
Facts about Ubiquitin-protein ligase E3A.
Ubiquitin-protein ligase E3A (UBE3A)
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transports it to its substrates (PubMed:10373495, PubMed:16772533, PubMed:19204938, PubMed:19233847, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24273172, PubMed:24728990). Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PubMed:10373495, PubMed:19204938, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24728990).
Additionally, may be a cellular excellent control ubiquitin ligase by assisting the degradation of the cytoplasmic misfolded proteins (PubMed:19233847). In the end, UBE3A also promotes its own degradation in vivo.
Gene Information
| Human | |
|---|---|
| Gene Name: | UBE3A |
| Uniprot: | Q05086 |
| Entrez: | 7337 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ANCR; ANCREPVE6AP; AS; CTCL tumor antigen se37-2; E6AP ubiquitin-protein ligase; E6AP; E6-AP; EC 6.3.2.-; EPVE6AP; FLJ26981; HPVE6A; human papilloma virus E6-associated protein; Human papillomavirus E6-associated protein; Oncogenic protein-associated protein E6-AP; Renal carcinoma antigen NY-REN-54; UBE3A; ubiquitin protein ligase E3A; ubiquitin-protein ligase E3A
Molecular Weight
Mass (kDA):
100.688 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q11.2 |
| Sequence: | 15; NC_000015.10 (25333728..25439381, complement) |
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Angelman Syndrome
- Prader-willi Syndrome
- Autistic Disorder
- Uniparental Disomy
- Malignant Neoplasms
- Neoplasms
- Epilepsy
- Ataxia
- Malignant Tumor Of Cervix
- Microcephaly
- Severe Mental Retardation
Interacting Proteins
- AHSP
- ASAP3
- ATG9A
- CGGBP1
- EIF3C
- EIF5A
- HERC2
- KLHL38
- MCM6
- PSMD4
Pathways
- Methylation
- Dna Methylation
- Pathogenesis
- Cell Cycle
- Localization
- Cell Proliferation
- Proteolysis
- Brain Development
- Senescence
- Cell Death
- Rna Interference
- Synaptic Transmission
- Histone Acetylation
PTMs
- Methylation
- Ubiquitination
- Phosphorylation
- Acetylation
Research Areas
- Apoptosis
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UBE3A
bosterbio.com/bosterbio-gene-info-cards/UBE3A
References
PMID: 9143503 by Yamamoto Y., et al. The human E6-AP gene (UBE3A) encodes three potential protein isoforms generated by differential splicing.
PMID: 8988171 by Kishino T., et al. UBE3A/E6-AP mutations cause Angelman syndrome.