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We validate the specificity of these antibodies to UCHL1 by testing them on tissues known to express UCHL1 positively and negatively. Browse below to find the UCHL1 antibody that suites your experiment. We have 10 of these antibodies and many publications and validation images.
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Facts about Ubiquitin carboxyl-terminal hydrolase isozyme L1.
Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
|peptidase C12 family|
EC 22.214.171.124; EC 6.-; Neuron cytoplasmic protein 9.5; PARK5; PGP 9.5; PGP9.5; PGP9.5Uch-L1; PGP95; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin C-terminal hydrolase; Ubiquitin thioesterase L1; UCHL1; UCH-L1
|Sequence:||4; NC_000004.12 (41256928..41268455)|
Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients.
Cytoplasm. Endoplasmic reticulum membrane; Lipid-anchor. About 30% of total UCHL1 is associated with membranes in brain.
The UCHL1 marker is an enzyme specific to neurons. This enzyme is responsible for deubiquitination and promotes neuronal differentiation. This enzyme is also important for cardiac function after an MI. Read on to learn more about UCHL1 and its uses. You will be glad you read this article! Boster Bio: Best Uses Of The UCHL1 Marker
UCHL1 is an enzyme that is expressed in the neurons of the brain and in the testis and ovary. The enzyme is responsible for enhancing the stability of the ubiquitin moiety. Its purification and analysis shows that it is a neuron-specific enzyme that is expressed at higher levels in neurons than in other tissues. This enzyme is also expressed in the brain at higher concentrations than in other tissues and it has been found to be a major component of neuronal cytoplasm.
Knocking down UCHL1 in NB cells has been shown to promote the differentiation of these cells. In addition, knockdown of UCHL1 inhibits phosphorylation of ERK1/2 and AKT, which are important for neuronal development. Moreover, knockdown of UCHL1 inhibits the expression of other genes associated with neuronal differentiation.
UCHL1 is an essential regulator of NB cell differentiation and may also provide novel therapeutic targets for NB. Moreover, UCHL1 expression correlates with clinical and pathological parameters. Survival analys Best nzyme