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- Table of Contents
ULK1 Antibodies
AND ULK1 ELISA kits, ULK1 Proteins
Many biological assays use antibodies to detect ULK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ULK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ULK1 antibodies...
Designing a Western blot for ULK1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ULK1 Western Blot GuideULK1 Infographic by Boster Bio
All ULK1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # A00584-1
100 μg/vial
Cat # A00584-1
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00584
100 μl
Cat # M00584
100 μl
Human, Mouse
IF, ICC, WB
$370
Cat # M00584S556
100 µl/vial
Cat # M00584S556
100 µl/vial
ULK1 Overview
Facts about Serine/threonine-protein kinase ULK1.
Serine/threonine-protein kinase ULK1 (ULK1)
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes.
Section of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, resulting in negatively regulate AMPK activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | ULK1 |
| Uniprot: | O75385 |
| Entrez: | 8408 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
ATG1 autophagy related 1 homolog; ATG1; ATG1A; EC 2.7.11; EC 2.7.11.1; FLJ38455; FLJ46475; KIAA0722; serine/threonine-protein kinase ULK1; unc-51 (C. elegans)-like kinase 1; UNC51; Unc51.1; unc-51-like kinase 1 (C. elegans); Unc-51-like kinase 1
Molecular Weight
Mass (kDA):
112.631 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.33 |
| Sequence: | 12; NC_000012.12 (131894622..131923150) |
Tissue Specificity
Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.
Subcellular Localizations
Cytoplasm, cytosol. Preautophagosomal structure. Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome.
Diseases
- Malignant Neoplasms
- Neoplasms
- Tissue Adhesions
- Carcinoma
- Physiological Stress
- Nerve Degeneration
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Crohn Disease
- Hypoxia
- Lymphoma
- Malignant Paraganglionic Neoplasm
Interacting Proteins
- AMBRA1
- ATG13
- GABARAPL1
- GABARAPL2
- HTT
- MAP1LC3B
- MAP1LC3C
- MTOR
- NTRK1
- PDPK1
Pathways
- Autophagy
- Cell Death
- Macroautophagy
- Localization
- Regulation Of Autophagy
- Response To Nutrient
- Transport
- Cellular Homeostasis
- Catabolic Process
- Cell Growth
- Cell Proliferation
- Energy Homeostasis
- Conjugation
PTMs
- Phosphorylation
- Dephosphorylation
Research Areas
- Autophagy
- mTOR Pathway
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ULK1
bosterbio.com/bosterbio-gene-info-cards/ULK1
References
PMID: 9693035 by Kuroyanagi H., et al. Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment.
PMID: 11146101 by Okazaki N., et al. Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation.