This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
1 Q&As
Facts about Serine/threonine-protein kinase ULK3.
Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and boosting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently.
Human | |
---|---|
Gene Name: | ULK3 |
Uniprot: | Q6PHR2 |
Entrez: | 25989 |
Belongs to: |
---|
protein kinase superfamily |
DKFZP434C131; EC 2.7.11.1; FLJ90566; serine/threonine-protein kinase ULK3; unc-51-like kinase 3 (C. elegans); Unc-51-like kinase 3
Mass (kDA):
53.444 kDA
Human | |
---|---|
Location: | 15q24.1 |
Sequence: | 15; NC_000015.10 (74836118..74843166, complement) |
Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest expression in the hippocampus, high levels also detected in the cerebellum, olfactory bulb and optic nerve. In the central nervous system, lowest levels in the spinal cord.
Cytoplasm. Localizes to pre-autophagosomal structure during cellular senescence.
You might be curious as to Steven Boster's history. This article will provide information about his background as well as his thoughts on the ULK3 marker. You might be surprised at the things you'll discover! You'll be amazed at the ULK3 marker's amazing features! It's also possible to use it for your research projects. So get ready to become a scientist.
You can find out more about Steven Boster by visiting the following link. The public records on Steve Boster will provide information about his past and current addresses, along with his mobile and email number and any known relatives. You can also search by state or age to view his relatives. Below, you can read more about Steve Boster's life and other notable achievements.
Stephen James Boster, a son of James and Evelyn Meier Boster, was born April 15, 1924 in Joliet (Illinois). He was the child of Evelyn Meier Boster and James Meier Boster. He was a manager for retail sales for many years. He served in the U.S. Army for many years and was a member Concordia Hall, Staunton, VA. Nina Mae, his wife, died in 2009. His daughter Crystal Boster, and his son Jonathan Boster, along with his sister Kimberly & niece Tammy, survive him.
Dr. Peter Seidman, a physician, has published an opinion essay on the ULK3 mark. This article discusses ULK1's importance, and the interaction between ULK1 (and ULK2) in detail. This paper also outlines the roles of both markers. Furthermore, Dr. Seidman’s views are based upon the findings from his laboratory. Earlier, Dr. Seidman's group had discovered that ULK1 and ULK2 have tissue-specific interactions.
His study reveals that ULK1 and ULK2 both play important roles in controlling apoptosis. The two genes are closely related, and one might compensate for the other. The body will not respond properly if one or both of these genes are missing. Alternatively, the missing gene will trigger the insufficient response. A number of transcription factors regulate the ULK3 Gene.
PMID: 19279323 by Young A.R., et al. Autophagy mediates the mitotic senescence transition.
PMID: 19878745 by Maloverjan A., et al. Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway.