Ubiquitin carboxyl-terminal hydrolase 11 (USP11)

Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799). Inhibits the degradation of target proteins by the proteasome (PubMed:12084015).

Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with'Lys-11' and'Lys-33'-linked ubiquitin chains, and extremely low activity with'Lys-27','Lys-29' and'Lys-48'- linked ubiquitin chains (in vitro) (PubMed:24724799).