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- Table of Contents
USP11 Antibodies
AND USP11 ELISA kits, USP11 Proteins
Many biological assays use antibodies to detect USP11, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with USP11 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop USP11 antibodies...
Designing a Western blot for USP11? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the USP11 Western Blot GuideUSP11 Infographic by Boster Bio
All USP11 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M05225
100 μl
Cat # M05225
100 μl
USP11 Overview
Facts about Ubiquitin carboxyl-terminal hydrolase 11.
Ubiquitin carboxyl-terminal hydrolase 11 (USP11)
Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799). Inhibits the degradation of target proteins by the proteasome (PubMed:12084015).
Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with'Lys-11' and'Lys-33'-linked ubiquitin chains, and extremely low activity with'Lys-27','Lys-29' and'Lys-48'- linked ubiquitin chains (in vitro) (PubMed:24724799).
Gene Information
| Human | |
|---|---|
| Gene Name: | USP11 |
| Uniprot: | P51784 |
| Entrez: | 8237 |
Family
| Belongs to: |
|---|
| peptidase C19 family |
Alternative Names
Deubiquitinating enzyme 11; EC 3.1.2.15; EC 3.4.19.12; ubiquitin carboxyl-terminal hydrolase 11; ubiquitin specific peptidase 11; ubiquitin specific protease 11; Ubiquitin Thioesterase 11; Ubiquitin thiolesterase 11; ubiquitin-specific processing protease 11; Ubiquitin-specific-processing protease 11; UHX1; UHX1ubiquitin carboxyl-terminal hydrolase, X-linked; USP11
Molecular Weight
Mass (kDA):
109.817 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp11.3 |
| Sequence: | X; NC_000023.11 (47233009..47248328) |
Subcellular Localizations
Nucleus. Cytoplasm. Chromosome. Predominantly nuclear (PubMed:12084015, PubMed:15314155). Associates with chromatin (PubMed:20601937, PubMed:20233726).
Diseases
- Malignant Neoplasms
- Neoplasms
- Retinal Diseases
- Night Blindness
- Malignant Neoplasm Of Breast
- Uterine Cervical Neoplasm
- Bone Neoplasms
- Malignant Tumor Of Cervix
- Carcinogenesis
- Osteosarcoma
- Malignant Neoplasm Of Ovary
- Influenza
Interacting Proteins
- BMI1
- CBX8
- PALB2
- PCGF2
- RING1
- RNF2
Pathways
- Response To Tumor Necrosis Factor
- Quorum Sensing
- Proteolysis
- Hypersensitivity
- Cell Growth
- Rna Interference
- Conjugation
- Double-strand Break Repair
PTMs
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/USP11
bosterbio.com/bosterbio-gene-info-cards/USP11
References
PMID: 12084015 by Ideguchi H., et al. Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM.
PMID: 8845848 by Swanson D.A., et al. A ubiquitin C-terminal hydrolase gene on the proximal short arm of the X chromosome: implications for X-linked retinal disorders.