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USP28 Antibodies
AND USP28 ELISA kits, USP28 Proteins
Many biological assays use antibodies to detect USP28, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with USP28 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop USP28 antibodies...
Designing a Western blot for USP28? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the USP28 Western Blot GuideUSP28 Infographic by Boster Bio
All USP28 Products
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USP28 Overview
Facts about Ubiquitin carboxyl-terminal hydrolase 28.
Ubiquitin carboxyl-terminal hydrolase 28 (USP28)
Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C).
By comparison, it doesn't deubiquitinate PLK1. Especially deubiquitinates MYC in the nucleoplasm, leading to avoid MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) from the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex.
Gene Information
| Human | |
|---|---|
| Gene Name: | USP28 |
| Uniprot: | Q96RU2 |
| Entrez: | 57646 |
Family
| Belongs to: |
|---|
| peptidase C19 family |
Alternative Names
Deubiquitinating enzyme 28; EC 3.1.2.15; EC 3.4.19.12; KIAA1515ubiquitin carboxyl-terminal hydrolase 28; ubiquitin specific peptidase 28; ubiquitin specific protease 28; ubiquitin thioesterase 28; Ubiquitin thiolesterase 28; Ubiquitin-specific-processing protease 28; USP28
Molecular Weight
Mass (kDA):
122.491 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q23.2 |
| Sequence: | 11; NC_000011.10 (113797875..113875572, complement) |
Subcellular Localizations
Nucleus, nucleoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Neoplasm Metastasis
- Colonic Neoplasms
- Hypoxia
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Fanconi Anemia
- Disuse Muscle Atrophy
- Malignant Neoplasm Of Breast
- Confusion
- Malignant Tumor Of Colon
Pathways
- Cell Growth
- Protein Phosphorylation
- Cell Proliferation
- Cell Migration
- Mitosis
- Dna Methylation
- Dna Repair
- Proteolysis
- Muscle Atrophy
PTMs
- Phosphorylation
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/USP28
bosterbio.com/bosterbio-gene-info-cards/USP28
References
PMID: 11597335 by Valero R., et al. Characterization of alternatively spliced products and tissue- specific isoforms of USP28 and USP25.
PMID: 16901786 by Zhang D., et al. A role for the deubiquitinating enzyme USP28 in control of the DNA- damage response.