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- Table of Contents
USP5 Antibodies
AND USP5 ELISA kits, USP5 Proteins
Many biological assays use antibodies to detect USP5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with USP5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop USP5 antibodies...
Designing a Western blot for USP5? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the USP5 Western Blot GuideDesigning an IHC experiment for USP5? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the USP5 IHC GuideUSP5 Infographic by Boster Bio
All USP5 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A04550-1
100 μg/vial
Cat # A04550-1
100 μg/vial
Human
$628
Cat # LS373509
20 µg, 100 µg
Cat # LS373509
20 µg, 100 µg
USP5 Overview
Facts about Ubiquitin carboxyl-terminal hydrolase 5.
Ubiquitin carboxyl-terminal hydrolase 5 (USP5)
Cleaves linear and branched multiubiquitin polymers with a marked taste for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly.
Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 induces the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to contend with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Gene Information
| Human | |
|---|---|
| Gene Name: | USP5 |
| Uniprot: | P45974 |
| Entrez: | 8078 |
Family
| Belongs to: |
|---|
| peptidase C19 family |
Alternative Names
Deubiquitinating enzyme 5; EC 3.1.2.15; EC 3.4.19.12; Isopeptidase T; IsoT; ISOTubiquitin carboxyl-terminal hydrolase 5; ubiquitin isopeptidase T; ubiquitin specific peptidase 5 (isopeptidase T); ubiquitin specific protease 5 (isopeptidase T); ubiquitin thioesterase 5; Ubiquitin thiolesterase 5; ubiquitin-specific protease-5 (ubiquitin isopeptidase T); Ubiquitin-specific-processing protease 5; USP5
Molecular Weight
Mass (kDA):
95.786 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12p13.31 |
| Sequence: | 12; NC_000012.12 (6852138..6866632) |
Diseases
- Neoplasms
- Malignant Neoplasms
- Malignant Paraganglionic Neoplasm
- Cell Invasion
- Cell Transformation, Neoplastic
- Neoplasm Metastasis
- Liver Carcinoma
- Glioblastoma
- Malignant Tumor Of Cervix
- Carcinoma
- Cancer Patients And Suicide And Depression
- Virus Diseases
Interacting Proteins
- DAZAP2
- RAD23B
- TADA3
- TMEM239
Pathways
- Localization
- Conjugation
- Transport
- Notch Signaling Pathway
- Cell Cycle
- Proteolysis
- Cell Growth
- Angiogenesis
- Protein Ubiquitination
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/USP5
bosterbio.com/bosterbio-gene-info-cards/USP5
References
PMID: 7498549 by Falquet L., et al. cDNA cloning of a human 100 kDa de-ubiquitinating enzyme: the 100 kDa human de-ubiquitinase belongs to the ubiquitin C-terminal hydrolase family 2 (UCH2).
PMID: 8723724 by Ansari-Lari M.A., et al. A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13.