Vacuolar protein sorting-associated protein 4B (VPS4B)

Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly together with membrane fission.

Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes allowing degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids.