Syndetin (VPS50)

Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) into the plasma membrane.

Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes into the trans-Golgi network (TGN).