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Wdr61 Antibodies
AND Wdr61 ELISA kits, Wdr61 Proteins
Many biological assays use antibodies to detect Wdr61, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Wdr61 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Wdr61 antibodies...
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Wdr61 Infographic by Boster Bio
All Wdr61 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$523
Cat # M12524
100 µl
Cat # M12524
100 µl
Wdr61 Overview
Facts about WD repeat-containing protein 61.
WD repeat-containing protein 61 (Wdr61)
Part of the PAF1 complex (PAF1C) that has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through discussion with POLR2A CTD non- phosphorylated and'Ser-2'- and'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1.
PAF1C is necessary for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Wdr61 |
| Uniprot: | Q9ERF3 |
| Entrez: | 66317 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Meiotic recombination REC14 protein homolog; REC14; recombination protein REC14; SKI8; WD repeat domain 61; WD repeat-containing protein 61
Molecular Weight
Mass (kDA):
33.773 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 9|9 A5.3 |
| Sequence: | 9; |
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Wdr61
bosterbio.com/bosterbio-gene-info-cards/Wdr61
References
PMID: 19345177 by Ding L., et al. A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.
PMID: 27749823 by Strikoudis A., et al. Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a.