WSB1 Antibodies

AND WSB1 ELISA kits, WSB1 Proteins

Many biological assays use antibodies to detect WSB1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WSB1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WSB1 antibodies...

We validate the specificity of these antibodies to WSB1 by testing them on tissues known to express WSB1 positively and negatively. Browse below to find the WSB1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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WSB1 Infographic by Boster Bio

All WSB1 Products

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Anti-WSB1 Antibody

Western blot analysis of WSB1 in human colon tissue lysate with WSB1 antibody at 1 μg/ml

Human

ELISA, IF, IHC-P, WB

$481
Cat # A07445
0.1 mg

WSB1 (NM_015626) Human Over-expression Lysate

WSB1 Human Over-expression Lysates NM_015626

Human

$628
Cat # LS026118
20 µg, 100 µg

WSB1 Overview

Facts about WD repeat and SOCS box-containing protein 1.

WSB1 3D structure. Source: alphafold

WD repeat and SOCS box-containing protein 1 (WSB1)

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2.

Confers constitutive instability to HIPK2 through proteasomal degradation. .

Gene Information

Human
Gene Name:	WSB1
Uniprot:	Q9Y6I7
Entrez:	26118

Family

Belongs to:

No superfamily

Alternative Names

DKFZp564B0482; SOCS box-containing WD protein SWiP-1; SWIP1DKFZp564A122; WD repeat and SOCS box containing 1; WD repeat and SOCS box-containing 1; WD repeat and SOCS box-containing protein 1; WSB-1

Molecular Weight

Mass (kDA):
47.432 kDA

Genomic Context


Human

Location:	17q11.1
Sequence:	17; NC_000017.11 (27294080..27315926)

Diseases

Neoplasms
Malignant Neoplasms
Neoplasm Metastasis
Von Hippel-lindau Syndrome
Hypoxia
Myeloid Leukemia, Chronic
Inflammatory Response
Myeloid Leukemia
Exhaustion
Pancreatic Neoplasm
Malignant Neoplasm Of Pancreas
Bacterial Infections

Neuroblastoma
Hereditary Diseases
Liver Carcinoma
Chronic Inflammation
Neurofibromatosis 1
Neurofibromatoses

Interacting Proteins

Hipk2
LRRK2

Pathways

Cell Proliferation
Cell Growth
Transport
Endosomal Transport
Induction Of Apoptosis
Cell Cycle
Fertilization
Dna Recombination
Chondrocyte Differentiation

Inflammatory Response
Secretion
Embryo Development

PTMs

Ubiquitination

Phosphorylation

Glycosylation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WSB1

References

PMID: 10354473 by Vasiliauskas D., et al. SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development.

PMID: 15601820 by Kamura T., et al. VHL-box and SOCS-box domains determine binding specificity for Cul2- Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.