This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
XIAP-associated factor 1 Antibodies
AND XAF1 ELISA kits, XIAP-associated factor 1 Proteins
Many biological assays use antibodies to detect XIAP-associated factor 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with XIAP-associated factor 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop XIAP-associated factor 1 antibodies...
Designing a Western blot for XIAP-associated factor 1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the XAF1 Western Blot GuideXAF1 Infographic by Boster Bio
All XAF1 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, ICC, WB
$370
Cat # PA1218
100 μg/vial
Cat # PA1218
100 μg/vial
XAF1 Overview
Facts about XIAP-associated factor 1.
XIAP-associated factor 1 (XAF1)
Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Induces cleavage and inactivation of BIRC4 independent of caspase activation.
Mediates TNF-alpha- induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway.
Gene Information
| Human | |
|---|---|
| Gene Name: | XAF1 |
| Uniprot: | Q6GPH4 |
| Entrez: | 54739 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BIRC4-binding protein; BIRC4BPBIRC4 binding protein; HSXIAPAF1; XIAP associated factor 1; XIAPAF1XIAP-associated factor 1
Molecular Weight
Mass (kDA):
34.626 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.1 |
| Sequence: | 17; NC_000017.11 (6755408..6775647) |
Tissue Specificity
Widely expressed. Expression is frequently down-regulated in cancer cell lines. Isoform 5 is widely expressed. Expressed in placenta (at protein level).
Subcellular Localizations
Cytoplasm. Nucleus. Mitochondrion. Found in the cytoplasm and nucleus of placental syncytiotrophoblasts. Translocates to mitochondria upon TNF-alpha treatment.; [Isoform 1]: Nucleus.; [Isoform 5]: Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Tumor Of Colon
- Colonic Neoplasms
- Stomach Neoplasms
- Cell Transformation, Neoplastic
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Stomach
- Carcinogenesis
- Tumor Progression
- Malignant Neoplasm Of Gastrointestinal Tract
Interacting Proteins
- RNF166
Pathways
- Methylation
- Cell Death
- Cell Cycle
- Cell Proliferation
- Cell Growth
- Gene Silencing
- Dna Methylation
- Pathogenesis
- Programmed Cell Death
- Localization
- Cell Cycle Arrest
- Sensitization
- Demethylation
PTMs
- Methylation
- Demethylation
- Phosphorylation
Research Areas
- Apoptosis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/XAF1
bosterbio.com/bosterbio-gene-info-cards/XAF1
References
PMID: 11175744 by Liston P., et al. Identification of XAF1 as an antagonist of XIAP anti-Caspase activity.
PMID: 17570219 by Chung S.K., et al. Frequent alteration of XAF1 in human colorectal cancers: implication for tumor cell resistance to apoptotic stresses.