Z-DNA-binding protein 1 (Zbp1)

Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against germs and pathogens.

Referred to as a cytoplasmic DNA sensor that, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably includes the recruitment of the RHIM containing kinases RIPK1 and RIPK3.