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Zinc finger protein 521 Antibodies
AND ZNF521 ELISA kits, Zinc finger protein 521 Proteins
Many biological assays use antibodies to detect Zinc finger protein 521, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Zinc finger protein 521 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Zinc finger protein 521 antibodies...
Designing an IHC experiment for Zinc finger protein 521? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ZNF521 IHC GuideZNF521 Infographic by Boster Bio
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ZNF521 Overview
Facts about Zinc finger protein 521.
Zinc finger protein 521 (ZNF521)
Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system.
Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes.
Gene Information
| Human | |
|---|---|
| Gene Name: | ZNF521 |
| Uniprot: | Q96K83 |
| Entrez: | 25925 |
Family
| Belongs to: |
|---|
| krueppel C2H2-type zinc-finger protein family |
Alternative Names
EHZF; Evi3; LIP3; ZFP521; zinc finger protein 263; Zinc finger protein FPM315; Zinc finger protein with KRAB and SCAN domains 12
Molecular Weight
Mass (kDA):
147.866 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18q11.2 |
| Sequence: | 18; NC_000018.10 (25061924..25352194, complement) |
Tissue Specificity
Predominantly expressed in hematopoietic cells. Present in organs and tissues that contain stem and progenitor cells, myeloid and/or lymphoid: placenta, spleen, lymph nodes, thymus, bone marrow and fetal liver. Within the hematopoietic system, it is abundant in CD34(+) cells but undetectable in mature peripheral blood leukocytes, and its levels rapidly decrease during the differentiation of CD34(+) cells in response to hemopoietins.
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Leukemia
- Cell Transformation, Neoplastic
- Hematopoietic Neoplasms
- Acute Lymphocytic Leukemia
- Malignant Tumor Of Cervix
- Carcinoma
- Virus Diseases
Pathways
- Histone Deacetylation
- Gene Silencing
- Cell Differentiation
- Cell Recognition
- Oncogenesis
PTMs
- Isopeptide bond
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ZNF521
bosterbio.com/bosterbio-gene-info-cards/ZNF521
References
PMID: 14630787 by Bond H.M., et al. Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells.
PMID: 17344859 by Mullighan C.G., et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia.