ZNRF1 Antibodies

AND ZNRF1 ELISA kits, ZNRF1 Proteins

Many biological assays use antibodies to detect ZNRF1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ZNRF1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ZNRF1 antibodies...

We validate the specificity of these antibodies to ZNRF1 by testing them on tissues known to express ZNRF1 positively and negatively. Browse below to find the ZNRF1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ZNRF1 Infographic by Boster Bio

All ZNRF1 Products

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Specificity

Applications

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Anti-ZNRF1 Antibody

Western blot analysis of lysates from HCT116 cells, primary antibody was diluted at 1:1000, 4°over night

Human, Mouse

ELISA, WB

$380
Cat # A10050
100ul

ZNRF1 (NM_032268) Human Over-expression Lysate

Human

$628
Cat # LS084937
20 µg, 100 µg

ZNRF1 Overview

Facts about E3 ubiquitin-protein ligase ZNRF1.

ZNRF1 3D structure. Source: alphafold

E3 ubiquitin-protein ligase ZNRF1 (ZNRF1)

E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity.

Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).

Gene Information

Human
Gene Name:	ZNRF1
Uniprot:	Q8ND25
Entrez:	84937

Family

Belongs to:

No superfamily

Alternative Names

DKFZp434E229; EC 6.3.2; EC 6.3.2.-; FLJ14846; MGC15430; nerve injury gene 283; Nerve injury-induced gene 283 protein; nin283; NIN283E3 ubiquitin-protein ligase ZNRF1; zinc and ring finger 1; zinc and ring finger protein 1; Zinc/RING finger protein 1

Molecular Weight

Mass (kDA):
23.783 kDA

Genomic Context


Human

Location:	16q23.1
Sequence:	16; NC_000016.10 (74999024..75110994)

Tissue Specificity

Expressed primarily in the nervous system, with expression higher in developing brain relative to adult. Expressed at low levels in testis and thymus.

Subcellular Localizations

Endosome. Lysosome. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Associated with synaptic vesicle membranes in neurons.