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- Table of Contents
Cysteine protease ATG4C Antibodies
AND ATG4C ELISA kits, Cysteine protease ATG4C Proteins
Many biological assays use antibodies to detect Cysteine protease ATG4C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cysteine protease ATG4C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cysteine protease ATG4C antibodies...
Designing an IHC experiment for Cysteine protease ATG4C? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ATG4C IHC GuideATG4C Infographic by Boster Bio
All ATG4C Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A09728-2
100 μg/vial
Cat # A09728-2
100 μg/vial
Human, Mouse, Rat
ELISA, IF, IHC-P, WB
$481
Cat # A09728
0.1 mg
Cat # A09728
0.1 mg
ATG4C Overview
Facts about Cysteine protease ATG4C.
Cysteine protease ATG4C (ATG4C)
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not vital for autophagy development under normal conditions but is required for a correct autophagic response under stressful conditions such as prolonged starvation (By similarity).
Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to show a C-terminal glycine. Exposure of the glycine at the C-terminus is vital for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is essential for autophagy.
Gene Information
| Human | |
|---|---|
| Gene Name: | ATG4C |
| Uniprot: | Q96DT6 |
| Entrez: | 84938 |
Family
| Belongs to: |
|---|
| peptidase C54 family |
Alternative Names
APG4 autophagy 4 homolog C (S. cerevisiae); APG4 autophagy 4 homolog C; APG4C; ATG4 autophagy related 4 homolog C (S. cerevisiae); AUT (S. cerevisiae)-like 1, cysteine endopeptidase; AUT-like 1, cysteineendopeptidase (S. cerevisiae); AUTL1; AUTL3APG4-C; AUT-like 1, cysteine endopeptidase; AUT-like 3 cysteine endopeptidase; autophagin-3; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C; cysteine protease ATG4C; EC 3.4.22; EC 3.4.22.-; FLJ14867
Molecular Weight
Mass (kDA):
52.497 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p31.3 |
| Sequence: | 1; NC_000001.11 (62783765..62865516) |
Tissue Specificity
Highly expressed in skeletal muscle, heart, liver and testis.
Subcellular Localizations
Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Inflammatory Bowel Diseases
- Intestinal Diseases
- Malignant Neoplasm Of Prostate
- Adenoma
- Neurodegenerative Disorders
- Nerve Degeneration
- Tumor Progression
- Nervous System Disorder
- Refractory Carcinoma
Pathways
- Autophagy
- Cell Death
- Aging
- Regulation Of Autophagy
- Oncogenesis
- Cytokine Production
- Sensitization
- Macroautophagy
PTMs
- Cleavage
Research Areas
- Autophagy
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATG4C
bosterbio.com/bosterbio-gene-info-cards/ATG4C
References
PMID: 12446702 by Marino G., et al. Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy.
PMID: 21177865 by Li M., et al. Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates.