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- Table of Contents
FASLG Antibodies
AND FASLG ELISA kits, FASLG Proteins
Many biological assays use antibodies to detect FASLG, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FASLG in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FASLG antibodies...
Designing a Western blot for FASLG? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the FASLG Western Blot GuideFASLG Infographic by Boster Bio
All FASLG Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$500
Cat # EZ0337
5 plates/kit
Cat # EZ0337
5 plates/kit
Human
ELISA
$499
Cat # EK0337
96 wells/kit, with removable strips.
Cat # EK0337
96 wells/kit, with removable strips.
Human
Cell Culture
$77
Cat # PROTP48023-4
5ug,20ug,100ug
Cat # PROTP48023-4
5ug,20ug,100ug
Mouse
Cell Culture
$77
Cat # PROTP41047
5ug,20ug,100ug
Cat # PROTP41047
5ug,20ug,100ug
FASLG Overview
Facts about Tumor necrosis factor ligand superfamily member 6.
Tumor necrosis factor ligand superfamily member 6 (FASLG)
Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:9228058, PubMed:7528780, PubMed:9427603).
Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | FASLG |
| Uniprot: | P48023 |
| Entrez: | 356 |
Family
| Belongs to: |
|---|
| tumor necrosis factor family |
Alternative Names
apoptosis (APO-1) antigen ligand 1; Apoptosis antigen ligand; APT1LG1CD95L; APTL; CD178 antigen; CD178; CD95L; CD95-L; Fas antigen ligand; Fas ligand (TNF superfamily, member 6); Fas Ligand; FASLCD95 ligand; FASLG; TNFSF6; TNFSF6FasL; tumor necrosis factor (ligand) superfamily, member 6; tumor necrosis factor ligand superfamily member 6
Molecular Weight
Mass (kDA):
31.485 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q24.3 |
| Sequence: | 1; NC_000001.11 (172659008..172666876) |
Subcellular Localizations
Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome lumen. Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination (PubMed:17164290). Colocalizes with the SPPL2A protease at the cell membrane (PubMed:17557115).; [Tumor necrosis factor ligand superfamily member 6, soluble form]: Secreted. May be released into the extracellular fluid by cleavage from the cell surface.; [FasL intracellular domain]: Nucleus. The FasL ICD cytoplasmic form is translocated into the nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Autoimmune Reaction
- Malignant Paraganglionic Neoplasm
- Inflammation
- Leukemia
- Autoimmune Diseases
- Adenocarcinoma
- Lymphoma
- Hiv Infections
- Hepatitis
- Neoplasm Metastasis
Interacting Proteins
- Ap2b1
- CASP8
- FADD
- FAS
- FNBP1
- FYN
- ITK
- KRT40
- NCK2
- NOTCH2NL
Pathways
- Cell Death
- Pathogenesis
- Induction Of Apoptosis
- Immune Response
- Programmed Cell Death
- Cell Proliferation
- Cell Cycle
- Secretion
- Cell Growth
- Cell Activation
- Localization
- Sensitization
- Inflammatory Response
PTMs
- Cleavage
- Phosphorylation
- Dephosphorylation
- Reduction
- Acetylation
- Methylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FASLG
bosterbio.com/bosterbio-gene-info-cards/FASLG
References
PMID: 7528780 by Alderson M.; Fas ligand mediates activation-induced cell death in human T lymphocytes.
PMID: 7826947 by Takahashi T., et al. Human Fas ligand: gene structure, chromosomal location and species specificity.
18 Publications of Boster FASLG Antibodies & ELISA Kits
- PubMed ID: 10.4049/jimmunol.1602175, The Upregulation of Integrin αDβ2 (CD11d/CD18) on Inflammatory Macrophages Pro...
- PubMed ID: 10.3390/ijms20040920, Potential Analysis and Preparation of Chitosan Oligosaccharides as Oral Nutritio...
- PubMed ID: 10.1155/2018/4310419, Amphiregulin Regulates Phagocytosis-Induced Cell Death in Monocytes via EGFR and...
- PubMed ID: 10.1080/0886022X.2018.1456938, Cisplatin-induced oxidative stress stimulates renal Fas ligand shedding
- PubMed ID: 10.1007/s11356-021-15453-6, Perfluorooctanoic acid exposure in early pregnancy induces oxidative stress in m...
- PubMed ID: 10.1002/stem.2210, Molecular and Cellular Functions Distinguish Superior Therapeutic Efficiency of ...
- PubMed ID: 10.1002/cbf.1523, Inhibitory effect of mesenchymal stem cells on lymphocyte proliferation
- PubMed ID: -, Lanfen Chen,Wei Chen,Mengbei Zhang et al.Comparison of therapeutic effects of me...
- PubMed ID: -, Yan Zhang,Linchao Zhang,JiaLu Bao et al.Perfluorooctanoic Acid Exposure in Early...
- PubMed ID: 30524196 , Amphiregulin Regulates Phagocytosis-Induced Cell Death in Monocytes via EGFR and...
- PubMed ID: 29619879, Cisplatin-induced oxidative stress stimulates renal Fas ligand shedding
- PubMed ID: 28500072, The upregulation of integrin ?D?2 (CD11d/CD18) on inflammatory macrophages promo...
- PubMed ID: 20222173, Li Q, Peng J, Li Xh, Liu T, Liang Qc, Zhang Gy. World J Gastroenterol. 2010 Mar ...
- PubMed ID: 19244542, Han X, Qiu L, Zhang Y, Kong Q, Wang H, Wang H, Li H, Duan C, Wang Y, Song Y, Wan...
- PubMed ID: 21159039, Xu J, Liu H, Wu Y, Gong X, Zhou Q, Qiao F. J Obstet Gynaecol Res. 2011 Mar;37(3)...
- PubMed ID: 20117771, Xiong M, Lu J, Zhao A, Xu L, Bao S, Lin Q, Yang B. Fertil Steril. 2010 May 15;93...
- PubMed ID: 24604244, Jiang H, Li J, Zhou T, Wang C, Zhang H, Wang H. Int J Mol Med. 2014 May;33(5):12...
- PubMed ID: 24714963, Wu Yh, Hu Sq, Liu J, Cao Hc, Xu W, Li Yj, Li Lj. Int J Mol Med. 2014 Jun;33(6):1...
*More publications can be found for each product on its corresponding product page