Anti-Aldehyde oxidase AOX1 Antibody

Product Name

Anti-Aldehyde oxidase AOX1 Antibody

View all Aldehyde Oxidase 1/AOX1 Antibodies

SKU/Catalog Number

A02144-2

Size

100ul

Form

Liquid

Description

Boster Bio Anti-Aldehyde oxidase AOX1 Antibody catalog # A02144-2. Tested in WB,IHC applications. This antibody reacts with Human,Mouse,Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Aldehyde oxidase AOX1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02144-2)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human AOX1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A02144-2 is reactive to AOX1 in Human, Mouse, Rat

Applications

A02144-2 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

147.918kDa

Background of Aldehyde Oxidase 1/AOX1

Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N-methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis.

Wright R.M., Proc. Natl. Acad. Sci. U.S.A. 90:10690-10694(1993).
Wright R.M., Redox Rep. 3:135-144(1997).
Hillier L.W., Nature 434:724-731(2005).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:500-1:1000
IHC: 1:50-1:200

Validation Images & Assay Conditions

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Figure 1. Western blotting validation for Anti-Aldehyde oxidase AOX1 Antibody A02144-2

Western blot (WB) analysis of AOX1 polyclonal antibody at 1:500 dilution
Lane1:MCF-7 cell lysate
Lane2:sp2/0 cell lysate
Lane3:PC12 cell lysate
Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration

Gene/Protein Information For AOX1 (Source: Uniprot.org, NCBI)

Alternative Names

Aldehyde Oxidase 1; aldehyde oxidase; AOAOH1; AOX1; EC 1.2.3.1 AOX1 AO, AOH1 aldehyde oxidase 1 aldehyde oxidase|azaheterocycle hydroxylase

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