Anti-AACT/SERPINA3 Antibody Picoband®

Product Name

Anti-AACT/SERPINA3 Antibody Picoband®

View all SERPINA3 Antibodies

SKU/Catalog Number

PA2217
BA3355 is an alternative SKU for this antibody, used in previous lots.

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-AACT/SERPINA3 Antibody catalog # PA2217. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

SERPINA3 (α1-antichymotrypsin) is described as a serpin superfamily plasma protease inhibitor; the page notes polymorphisms influence protease targeting, and sequence variations are implicated in Alzheimer’s disease with deficiency associated with liver disease. Assay context: Human-reactive antibody validated for IHC and Western blot (observed MW 57 kDa reported on-page; on-page IHC includes liver tissue contexts); tissue interpretation often benefits from standardized review criteria (method-context) such as pathology review, and protease/antiprotease balance can be discussed alongside cytotoxic granule proteases like GZMB (putative functional counterpoint).

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-AACT/SERPINA3 Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA2217)

Host

Rabbit

Contents

Each vial contains antibody formulated with stabilizing components, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
*This antibody is supplied in a stabilized formulation. Compatibility with conjugation reactions depends on the chemistry of the conjugation method used. For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human alpha 1 Antichymotrypsin.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA2217 is reactive to SERPINA3 in Human

Observed Molecular Weight

57 kDa

Calculated molecular weight

47.7 kDa

Background of SERPINA3

Alpha 1-antichymotrypsin, also called serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 or GIG24 is an alpha globulin glycoprotein that is a member of the serpin superfamily. In humans, it is encoded by the SERPINA3 gene. This gene is mapped to 14q32.13. The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

PA2217 is guaranteed for IHC, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human
Western blot, 0.1-0.5μg/ml, Human

Positive Control

WB: SMMC Cell
IHC: Human Liver Cancer Tissue

Validation Images & Assay Conditions

See full target information SERPINA3

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