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- Table of Contents
Alpha-1-antichymotrypsin Antibodies
AND SERPINA3 ELISA kits, Alpha-1-antichymotrypsin Proteins
Many biological assays use antibodies to detect Alpha-1-antichymotrypsin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Alpha-1-antichymotrypsin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Alpha-1-antichymotrypsin antibodies...
Designing an IHC experiment for Alpha-1-antichymotrypsin? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SERPINA3 IHC GuideSERPINA3 Infographic by Boster Bio
All SERPINA3 Products
Product
Figures
Specificity
Applications
Price
Human
IP, IF, IHC, ICC, WB
$370
Cat # M02312
100 μl
Cat # M02312
100 μl
Human
$628
Cat # LS000012
20 µg, 100 µg
Cat # LS000012
20 µg, 100 µg
SDS-PAGE
$243
Cat # PROTP01011
Starting from 20ug
Cat # PROTP01011
Starting from 20ug
SERPINA3 Overview
Facts about Alpha-1-antichymotrypsin.
Alpha-1-antichymotrypsin (SERPINA3)
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. .
Gene Information
| Human | |
|---|---|
| Gene Name: | SERPINA3 |
| Uniprot: | P01011 |
| Entrez: | 12 |
Family
| Belongs to: |
|---|
| serpin family |
Alternative Names
AACTMGC88254; ACTGIG25; alpha 1-Antichymotrypsin; alpha-1-antichymotrypsin; antitrypsin), member 3; Cell growth-inhibiting gene 24/25 protein; growth-inhibiting protein 24; growth-inhibiting protein 25; member 3; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase; serine (or cysteine) proteinase inhibitor, clade A, member 3; Serpin A3; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)
Molecular Weight
Mass (kDA):
47.651 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q32.13 |
| Sequence: | 14; NC_000014.9 (94612391..94624053) |
Tissue Specificity
Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
Subcellular Localizations
Secreted.
Diseases
- Malignant Neoplasms
- Inflammation
- Hemorrhage
- Alzheimer's Disease
- Neoplasms
- Aneurysm
- Subarachnoid Hemorrhage
- Hypertensive Disease
- Intracranial Aneurysm
- Fetal Growth Retardation
- Pre-eclampsia
- Chronic Obstructive Airway Disease
- Hemorrhage, Aneurysmal Subarachnoid
Interacting Proteins
- DNAJC1
Pathways
- Localization
- Cell Adhesion
- Coagulation
- Pathogenesis
- Immune Response
- Proteolysis
- Inflammatory Response
- Ovulation
- Cellular Localization
- Secretion
- Aging
- Protein Secretion
- Oxidative Phosphorylation
PTMs
- Cleavage
- Methylation
- Phosphorylation
Research Areas
- Breast Cancer
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SERPINA3
bosterbio.com/bosterbio-gene-info-cards/SERPINA3
References
PMID: 6606438 by Chandra T., et al. Sequence homology between human alpha 1-antichymotrypsin, alpha 1- antitrypsin, and antithrombin III.
PMID: 8244391 by Poller W., et al. A leucine-to-proline substitution causes a defective alpha 1- antichymotrypsin allele associated with familial obstructive lung disease.