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Product Info Summary
| SKU: | A00883-1 |
|---|---|
| Size: | 150 ul |
| Reactive Species: | Rat |
| Host: | Rabbit |
| Application: | IHC |
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Product info
Product Name
Anti-Alpha 2a Adrenergic Receptor ADRA2A Antibody
View all alpha-2A Adrenergic R/ADRA2A Antibodies
SKU/Catalog Number
A00883-1
Size
150 ul
Form
Liquid
Description
Boster Bio Anti-Alpha 2a Adrenergic Receptor ADRA2A Antibody (Catalog# A00883-1). Tested in IHC applications. This antibody reacts with Rat.
Storage & Handling
Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Alpha 2a Adrenergic Receptor ADRA2A Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00883-1)
Host
Rabbit
Contents
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Clonality
Polyclonal
Clone Number
10C3
Isotype
Rabbit IgG
Immunogen
(C)KASRWRGRQNREKR
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Detects ~20kDa. Does not cross-react with αB-crystallin, βL-crystallin, ΒH- crystallin, γ-crystallin, HSP25, HSP27 or HSP47 proteins.
Reactive Species
A00883-1 is reactive to ADRA2A in Rat
Applications
A00883-1 is guaranteed for IHC Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
50.647kDa
Background of alpha-2A Adrenergic R/ADRA2A
The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990; Hollmann and Heinemann, 1994). The GluR1 subunit is widely expressed throughout the nervous system. Phosphorylation of Ser-845 on GluR1 is thought to be mediated by PKA and phosphorylation of this site increases the conductance of the AMPAR (Roche et al., 1996; Banke et al., 2000). In addition, phosphorylation of this site has been linked to synaptic plasticity as well as learning and memory (Lee at al., 2003; Esteban at al., 2003).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Reconsitution
Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:1000
IHC: 1:1000
Validation Images & Assay Conditions
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Figure 2. Immunofluorescent staining data of ADRA2A using Anti-Alpha 2a Adrenergic Receptor ADRA2A Antibody (A00883-1).
Alpha 2 adrenergic receptor labeling in rat cryostat section of rat brain. Labeling is confined to synaptic boutons (red). Tissue nuclei were counterstasined with DAPI (blue).
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Figure 1. Validation data of ADRA2A using Anti-Alpha 2a Adrenergic Receptor ADRA2A Antibody (A00883-1).
Protein Target Info & Infographic
Gene/Protein Information For ADRA2A (Source: Uniprot.org, NCBI)
Gene Name
ADRA2A
Full Name
Alpha-2A adrenergic receptor
Weight
50.647kDa
Superfamily
G-protein coupled receptor 1 family
Alternative Names
a-2A AdrenergicR; ADRA2; ADRA2A; ADRA2Ralpha-2-adrenergic receptor, platelet type; ADRARZNF32; adrenergic, alpha-2A-, receptor; Alpha-2 adrenergic receptor subtype C10; alpha-2A Adrenergic R; alpha-2A adrenergic receptor; alpha2A AdrenergicR; Alpha-2A adrenoceptor; Alpha-2A adrenoreceptor; alpha-2AAR subtype C10; ALPHA2AAR; Alpha-2AAR; ZNF32 ADRA2A ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32 adrenoceptor alpha 2A alpha-2A adrenergic receptor|adrenergic, alpha-2A-, receptor|alpha-2 adrenergic receptor subtype C10|alpha-2-adrenergic receptor, platelet type|alpha-2A adrenoceptor|alpha-2A adrenoreceptor|alpha-2AAR subtype C10
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ADRA2A, check out the ADRA2A Infographic
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In this infographic, you will see the following information for ADRA2A: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Alpha 2a Adrenergic Receptor ADRA2A Antibody (A00883-1)
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