Anti-AOX1/Aldehyde Oxidase Antibody

Product Name

Anti-AOX1/Aldehyde Oxidase Antibody

View all Aldehyde Oxidase 1/AOX1 Antibodies

SKU/Catalog Number

A02144

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-AOX1/Aldehyde Oxidase Antibody (Catalog # A02144). Tested in WB, IHC applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-AOX1/Aldehyde Oxidase Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02144)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human AOX1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A02144 is reactive to AOX1 in Human

Applications

A02144 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

147.918kDa

Background of Aldehyde Oxidase 1/AOX1

Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N-methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis.

Wright R.M., Proc. Natl. Acad. Sci. U.S.A. 90:10690-10694(1993).
Wright R.M., Redox Rep. 3:135-144(1997).
Hillier L.W., Nature 434:724-731(2005).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Validation Images & Assay Conditions

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Western blot analysis of extracts from HeLa cells, using AOX1 antibody A02144.

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Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using AOX1 antibody A02144.

Gene/Protein Information For AOX1 (Source: Uniprot.org, NCBI)

Alternative Names

Aldehyde Oxidase 1; aldehyde oxidase; AOAOH1; AOX1; EC 1.2.3.1 AOX1 AO, AOH1 aldehyde oxidase 1 aldehyde oxidase|azaheterocycle hydroxylase

For more info on AOX1, check out the AOX1 Infographic

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In this infographic, you will see the following information for AOX1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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