Anti-Aromatase/CYP19A1 Antibody

Product Name

Anti-Aromatase/CYP19A1 Antibody

View all Aromatase Antibodies

SKU/Catalog Number

PA1489

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Aromatase/CYP19A1 Antibody catalog # PA1489. Tested in IHC, WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Aromatase/CYP19A1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1489)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Aromatase.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1489 is reactive to CYP19A1 in Human

Applications

PA1489 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

58 kDa

Calculated molecular weight

57.883kDa

Background of Aromatase

Aromatase is an enzyme responsible for a key step in the biosynthesis of estrogens. It is a member of the cytochrome P450 superfamily, which are monooxygenases that catalyze many reactions involved in steroidogenesis. In particular, aromatase is responsible for the aromatization of androgens into estrogens. The CYP19 gene spans at least 70 kb of genomic DNA and contains 10 exons. By in situ hybridization, the ARO gene is mapped to 15q21.1. The aromatase enzyme can be found in many tissues including gonads, brain, adipose tissue, placenta, blood vessels, skin, bone, and endometrium, as well as in tissue of endometriosis, uterine fibroids, breast cancer, and endometrial cancer. It is an important factor in sexual development. Some bodybuilders taking steroids also take antiaromatase supplements to prevent excess testosterone conversion into estrogens, which can cause gynecomastia.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human

Validation Images & Assay Conditions

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Anti-Aromatase antibody, PA1489, Western blotting
Lane 1: Human Placenta Tissue Lysate
Lane 2: Human Placenta Tissue Lysate

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Anti-Aromatase antibody, PA1489, IHC(P)
IHC(P): Human Placenta Tissue

Gene/Protein Information For CYP19A1 (Source: Uniprot.org, NCBI)

Alternative Names

ARO1EC 1.14.14.1; Aromatase; AROsubfamily XIX (aromatization of androgens); CYARMGC104309; CYPXIX; cytochrome P450, family 19, subfamily A, polypeptide 1; Cytochrome P-450AROM; Estrogen synthase; microsomal monooxygenase CYP19A1 ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM cytochrome P450 family 19 subfamily A member 1 aromatase|cytochrome P-450AROM|cytochrome P450 19A1|cytochrome P450, family 19, subfamily A, polypeptide 1|cytochrome P450, subfamily XIX (aromatization of androgens)|estrogen synthase|estrogen synthetase|flavoprotein-linked monooxygenase|microsomal monooxygenase

For more info on CYP19A1, check out the CYP19A1 Infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for CYP19A1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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