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Product Info Summary
| SKU: | A02874 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Autophagy-related protein 13 ATG13 Antibody
SKU/Catalog Number
A02874
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Autophagy-related protein 13 ATG13 Antibody (Catalog # A02874). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
ATG13 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Autophagy-related protein 13 ATG13 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02874)
Host
Rabbit
Contents
ATG13 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
Clone: SK7
Isotype
IgG
Immunogen
ATG13 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ATG13. The immunogen is located within amino acids 450 - 500 of ATG13.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Multiple isoforms of ATG13 are known to exist.
Reactive Species
A02874 is reactive to ATG13 in Human, Mouse, Rat
Applications
A02874 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
56.572kDa
Background of ATG13
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG13 forms a complex with ULK1 and ULK2, the mammalian homologs of ATG1, and with FIP200. This complex is a target of TOR phosphorylation under normal conditions; inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy. Knockdown of ATG13 inhibits autophagosome formation.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
ATG13 antibody can be used for detection of ATG13 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of ATG13 in rat heart tissue lysate with ATG13 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunohistochemistry of ATG13 in mouse heart with ATG13 antibody at 5 μg/mL.
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Immunofluorescence of ATG13 in Mouse Heart tissue with ATG13 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For ATG13 (Source: Uniprot.org, NCBI)
Gene Name
ATG13
Full Name
Autophagy-related protein 13
Weight
56.572kDa
Superfamily
ATG13 family
Alternative Names
autophagy-related protein 13; autophagy related 13; KIAA0652 ATG13 KIAA0652, PARATARG8 autophagy related 13 autophagy-related protein 13|ATG13 autophagy related 13 homolog
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ATG13, check out the ATG13 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ATG13: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Autophagy-related protein 13 ATG13 Antibody (A02874)
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No publications found for A02874
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Customer Reviews
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