Anti-AZI1 CEP131 Antibody

Product Name

Anti-AZI1 CEP131 Antibody

View all Cep131 Antibodies

SKU/Catalog Number

A07638

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-AZI1 CEP131 Antibody (Catalog # A07638). Tested in WB, IHC applications. This antibody reacts with Human, Mouse.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-AZI1 CEP131 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07638)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human AZI1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A07638 is reactive to Cep131 in Human, Mouse

Applications

A07638 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

120.313kDa

Background of Cep131

Component of centriolar satellites, which build a complex and dynamic network required to regulate cilia/flagellum formation. During normal and stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a p38 MAPK-dependent manner. In contrast, in proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. Acts also as a negative regulator for the trafficking from the centriolar satellite BBSome protein complex to the cilia. Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail. Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability and centriole duplication in non-ciliogenic cells.

Kikuno R., DNA Res. 6:197-205(1999).
Andersen J.S., Nature 426:570-574(2003).
Olsen J.V., Cell 127:635-648(2006).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Validation Images & Assay Conditions

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Western blot analysis of extracts from HUVEC cells, using AZI1 antibody A07638.

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Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using AZI1 antibody A07638.

Gene/Protein Information For Cep131 (Source: Uniprot.org, NCBI)

Alternative Names

Centrosomal protein of 131 kDa Cep131|AZ, AZ1, Azi, Azi1|centrosomal protein 131|centrosomal protein of 131 kDa|5-azacytidine induced gene 1|5-azacytidine-induced protein 1|pre-acrosome localization protein 1

For more info on Cep131, check out the Cep131 Infographic

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In this infographic, you will see the following information for Cep131: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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