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Product Info Summary
| SKU: | PA1845 |
|---|---|
| Size: | 100 μg/vial |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | IHC, WB |
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Product info
Product Name
Anti-Beta Arrestin 2/ARRB2 Antibody
View all beta-Arrestin 2 Antibodies
SKU/Catalog Number
PA1845
Size
100 μg/vial
Form
Lyophilized
Description
Boster Bio Anti-Beta Arrestin 2/ARRB2 Antibody catalog # PA1845. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Beta Arrestin 2/ARRB2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1845)
Host
Rabbit
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Beta Arrestin 2, different from the related rat and mouse sequences by two amino acids.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross-reactivity with other proteins
Reactive Species
PA1845 is reactive to ARRB2 in Human, Mouse, Rat
Applications
PA1845 is guaranteed for IHC, WB Boster Guarantee
Observed Molecular Weight
46 kDa
Calculated molecular weight
46.106kDa
Background of beta-Arrestin 2
ARRB2 (arrestin beta-2), also known as Beta-arrestin-2, BARR2, ARB2, DKFZp686L0365, arrestin 3, is an intracellularprotein that in humans is encoded by the ARRB2 gene. Members of arrestin/beta-arrestin protein family are though to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals, as well as having signalling roles in their own right. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Beta-arrestins were originally discovered in the context of heterotrimeric G protein-coupled receptor desensitization, but they also function in internalization and signaling of these receptors.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Reconsitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Rat, Mouse, By Heat
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
Validation Images & Assay Conditions
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Anti-Beta Arrestin 2 antibody, PA1845, IHC(P)
IHC(P): Human Intestinal Cancer Tissue
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Anti-Beta Arrestin 2 antibody, PA1845, IHC(P)
IHC(P): Rat Testis Tissue
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Anti-Beta Arrestin 2 antibody, PA1845, Western blotting
All lanes: Anti ARRB2 (PA1845) at 0.5ug/ml
Lane 1: HELA Whole Cell Lysate at 40ug
Lane 2: Rat Skeletal Muscle Tissue Lysate at 50ug
Predicted bind size: 46KD
Observed bind size: 46KD
Protein Target Info & Infographic
Gene/Protein Information For ARRB2 (Source: Uniprot.org, NCBI)
Gene Name
ARRB2
Full Name
Beta-arrestin-2
Weight
46.106kDa
Superfamily
arrestin family
Alternative Names
ARB2; ARR2; ARRB2; arrestin 3; Arrestin beta-2; arrestin, beta 2; BARR2; betaArrestin 2; beta-Arrestin 2; beta-arrestin-2; DKFZp686L0365 ARRB2 ARB2, ARR2, BARR2 arrestin beta 2 beta-arrestin-2|arrestin 3|non-visual arrestin-3
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ARRB2, check out the ARRB2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ARRB2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Beta Arrestin 2/ARRB2 Antibody (PA1845)
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No publications found for PA1845
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Customer Reviews
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Customer Q&As
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1 Customer Q&As for Anti-Beta Arrestin 2/ARRB2 Antibody
Question
We are currently using anti-Beta Arrestin 2/ARRB2 antibody PA1845 for rat tissue, and we are content with the IHC results. The species of reactivity given in the datasheet says human, mouse, rat. Is it possible that the antibody can work on zebrafish tissues as well?
Verified Customer
Verified customer
Asked: 2019-09-10
Answer
The anti-Beta Arrestin 2/ARRB2 antibody (PA1845) has not been validated for cross reactivity specifically with zebrafish tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in zebrafish you can get your next antibody for free. Please contact me if I can help you with anything.
Boster Scientific Support
Answered: 2019-09-10
