Product Info Summary
SKU: | A04212-1 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | IF, IHC |
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Product info
Product Name
Anti-BIG2 (L1527) ARFGEF2 Antibody
SKU/Catalog Number
A04212-1
Size
100ul
Form
Liquid
Description
Boster Bio Anti-BIG2 (L1527) ARFGEF2 Antibody catalog # A04212-1. Tested in IHC,IF applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-BIG2 (L1527) ARFGEF2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04212-1)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from internal of human ARFGEF2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A04212-1 is reactive to ARFGEF2 in Human, Mouse, Rat
Applications
A04212-1 is guaranteed for IF, IHC Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
202.038kDa
Background of ARFGEF2
Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extend on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.
Togawa A., J. Biol. Chem. 274:12308-12315(1999).
Deloukas P., Nature 414:865-871(2001).
Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004)
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IHC: 1:50-1:200
IF: 1:50-1:200
Validation Images & Assay Conditions
There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.
Protein Target Info & Infographic
Gene/Protein Information For ARFGEF2 (Source: Uniprot.org, NCBI)
Gene Name
ARFGEF2
Full Name
Brefeldin A-inhibited guanine nucleotide-exchange protein 2
Weight
202.038kDa
Alternative Names
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldinA-inhibited); ARFGEP2; BIG2brefeldin A-inhibited guanine nucleotide-exchange protein 2; Brefeldin A-inhibited GEP 2; dJ1164I10.1; FLJ23723; PVNH2 ARFGEF2 BIG2, PVNH2, dJ1164I10.1 ADP ribosylation factor guanine nucleotide exchange factor 2 brefeldin A-inhibited guanine nucleotide-exchange protein 2|ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)|brefeldin A-inhibited GEP 2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ARFGEF2, check out the ARFGEF2 Infographic
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In this infographic, you will see the following information for ARFGEF2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-BIG2 (L1527) ARFGEF2 Antibody (A04212-1)
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No publications found for A04212-1
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