Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2)

Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6.

Involved in the regulation of Golgi vesicular transport.

Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complicated and GGA1.