Anti-BRCA1 (Breast Marker) Monoclonal Antibody

BRCA1 antibody

Boster Bio Anti-BRCA1 (Breast Marker) Monoclonal Antibody catalog # M00005. Tested in IHC applications. This antibody reacts with Human. Cited in 1 publication(s).

Product Info Summary

SKU: M00005
Size: 100ug/vial
Reactive Species: Human
Host: Mouse
Application: IHC

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Product Name

Anti-BRCA1 (Breast Marker) Monoclonal Antibody

View all BRCA1 Antibodies

SKU/Catalog Number

M00005

Size

100ug/vial

Form

Liquid

Description

Boster Bio Anti-BRCA1 (Breast Marker) Monoclonal Antibody catalog # M00005. Tested in IHC applications. This antibody reacts with Human.

Storage & Handling

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Cite This Product

Anti-BRCA1 (Breast Marker) Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00005)

Host

Mouse

Contents

Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Clonality

Monoclonal

Clone Number

BRCA1/1398

Isotype

IgG1, kappa

Immunogen

Recombinant human BRCA1 protein fragment (aa445-620) (exact sequence is proprietary)

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M00005 is reactive to BRCA1 in Human

Applications

M00005 is guaranteed for IHC Boster Guarantee

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.

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Innovating Scientists Reward

If you are the first to review this product, or if you have results for a special sample, species or application this product is not validated in, share your results with us and receive product credits you can use towards any Boster products! Applicable to all scientists worldwide.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.

Immunohistology (Formalin-fixed) (5-10ug/ml for 60 minutes at RT)
Immunofluorescence (1-2ug/ml)

Validation Images & Assay Conditions

Gene/Protein Information For BRCA1 (Source: Uniprot.org, NCBI)

Uniprot ID

P38398

Gene ID

672

Gene Name

BRCA1

Full Name

Breast cancer type 1 susceptibility protein

Weight

207.721kDa

Alternative Names

BRCA1; BRCAI; breast and ovarian cancer susceptibility protein 1; breast and ovarian cancer sususceptibility protein; breast cancer 1, early onset; breast cancer type 1 susceptibility protein; EC 6.3.2; EC 6.3.2.-; IRIS; PNCA4; PSCP; subunit 1 BRCA1 BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4, PPP1R53, PSCP, RNF53 BRCA1 DNA repair associated breast cancer type 1 susceptibility protein|BRCA1/BRCA2-containing complex, subunit 1|Fanconi anemia, complementation group S|RING finger protein 53|breast and ovarian cancer susceptibility protein 1|breast cancer 1, early onset|early onset breast cancer 1|protein phosphatase 1, regulatory subunit 53

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on BRCA1, check out the BRCA1 Infographic

BRCA1 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for BRCA1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected]

M00005 has been cited in 1 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Zhang Q, Zhang Q, Cong H, Zhang X. Diagn Pathol. 2012 Dec 31;7:181. Doi: 10.1186/1746-1596-7-181. The Ectopic Expression Of Brca1 Is Associated With Genesis, Progression, And Prognosis Of Breast Cancer In Young Patients.

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3 Customer Q&As for Anti-BRCA1 (Breast Marker) Monoclonal Antibody

Question

We are currently using anti-BRCA1 (Breast Marker) Monoclonal antibody M00005 for human tissue, and we are well pleased with the IHC results. The species of reactivity given in the datasheet says human. Is it true that the antibody can work on goat tissues as well?

Verified Customer

Verified customer

Asked: 2020-04-10

Answer

The anti-BRCA1 (Breast Marker) Monoclonal antibody (M00005) has not been tested for cross reactivity specifically with goat tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in goat you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2020-04-10

Question

We have observed staining in human cervix carcinoma erythroleukemia. What should we do? Is anti-BRCA1 (Breast Marker) Monoclonal antibody supposed to stain cervix carcinoma erythroleukemia positively?

Verified Customer

Verified customer

Asked: 2019-12-13

Answer

According to literature cervix carcinoma erythroleukemia does express BRCA1. According to Uniprot.org, BRCA1 is expressed in lung, mammary gland, testis, pns, cervix carcinoma, embryonic kidney, leukemic t-cell, cervix carcinoma erythroleukemia, among other tissues. Regarding which tissues have BRCA1 expression, here are a few articles citing expression in various tissues:
Cervix carcinoma, Pubmed ID: 17081983, 18669648, 20068231
Cervix carcinoma, and Erythroleukemia, Pubmed ID: 23186163
Embryonic kidney, Pubmed ID: 17525332
Leukemic T-cell, Pubmed ID: 19690332
Mammary gland, Pubmed ID: 9010228
PNS, Pubmed ID: 15489334
Testis, Pubmed ID: 16625196

Boster Scientific Support

Answered: 2019-12-13

Question

My team were well pleased with the WB result of your anti-BRCA1 (Breast Marker) Monoclonal antibody. However we have been able to see positive staining in embryonic kidney nucleus using this antibody. Is that expected? Could you tell me where is BRCA1 supposed to be expressed?

Verified Customer

Verified customer

Asked: 2019-07-19

Answer

From what I have seen in literature, embryonic kidney does express BRCA1. Generally BRCA1 expresses in nucleus. Regarding which tissues have BRCA1 expression, here are a few articles citing expression in various tissues:
Cervix carcinoma, Pubmed ID: 17081983, 18669648, 20068231
Cervix carcinoma, and Erythroleukemia, Pubmed ID: 23186163
Embryonic kidney, Pubmed ID: 17525332
Leukemic T-cell, Pubmed ID: 19690332
Mammary gland, Pubmed ID: 9010228
PNS, Pubmed ID: 15489334
Testis, Pubmed ID: 16625196

Boster Scientific Support

Answered: 2019-07-19

Size

Total: $440

SKU:M00005

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Ships directly to USA and Canada. For other regions, visit our distributors page

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M00005
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$440.00

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