Anti-c-Myc Antibody (Monoclonal, 35M73)

Anti-c-Myc Antibody (Monoclonal, 35M73)
View all MYC Antibodies

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Mouse IgG in stabilizing components, 1.2% sodium acetate and 0.01mg NaN3.

35M73

Synthetic peptide corresponding to residues 408-439 of the human p62c-Myc protein.

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

C-Myc is an oncogene that functions both in the stimulation of cell proliferation and in apoptosis. c-Myc elicits its oncogenic activity by causing immortalization, and to a lesser extent the transformation of cells, in addition to several other mechanisms. The c-MYC proto-oncogene encodes a transcription factor that is critical for cell growth and proliferation. It is one of the genes frequently altered in cancer cells in which it exhibits constitutive activity. Downregulation of c-Myc is critical for 2-Methoxyestradiol (2ME2)-induced oxidative stress and apoptosis in AML cells. And its up-regulation is important for promoting lymphocyte cell division, and demonstrating that GFP-c-Myc expression is a marker of proliferating lymphocytes in vivo.